Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

被引:8
|
作者
Martic, Ines [1 ,2 ]
Papaccio, Federica [3 ,4 ]
Bellei, Barbara [3 ,4 ]
Cavinato, Maria [1 ,2 ]
机构
[1] Univ Innsbruck, Inst Biochem Aging Res, Innsbruck, Austria
[2] Ctr Mol Biosci Innsbruck CMBI, Innsbruck, Austria
[3] Istituti Ricovero & Cura Carattere Sci IRCCS, San Gallicano Dermatol Inst, Lab Cutaneous Physiopathol, Rome, Italy
[4] Istituti Ricovero & Cura Carattere Sci IRCCS, San Gallicano Dermatol Inst, Integrated Ctr Metabol Res, Rome, Italy
基金
奥地利科学基金会;
关键词
skin; aging; mitochondria; skin homeostasis; skin cells; HUMAN DERMAL FIBROBLASTS; MESENCHYMAL STEM-CELLS; UVB-INDUCED SENESCENCE; CELLULAR SENESCENCE; COENZYME Q(10); DNA DELETIONS; IN-VIVO; AGE; MELANOGENESIS; DYSFUNCTION;
D O I
10.3389/fphys.2023.1284410
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Aging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a crucial role in several cellular mechanisms such as energy production and free radical maintenance. However, mitochondrial metabolism as well as processes of mitochondrial dynamics, biogenesis, and degradation varies considerably among the different types of cells that populate the skin. Disturbed mitochondrial function is known to promote aging and inflammation of the skin, leading to impairment of physiological skin function and the onset of skin pathologies. In this review, we discuss the essential role of mitochondria in different skin cell types and how impairment of mitochondrial morphology, physiology, and metabolism in each of these cellular compartments of the skin contributes to the process of skin aging.
引用
收藏
页数:17
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