Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems

被引：3
|
作者：
Tan, Yaochong [1 ,2 ]
Dong, Xueting [1 ,2 ]
Zhuang, Donglin [3 ]
Cao, Buzi [4 ]
Jiang, Hua [5 ]
He, Qingnan [1 ]
Zhao, Mingyi [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 3, Dept Pediat, Changsha 410013, Hunan, Peoples R China
[2] Cent South Univ, Med Sch Xiangya, Changsha 410013, Hunan, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, China & Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Struct Heart Dis, Beijing 100037, Peoples R China
[4] Hunan Normal Univ, Sch Med, Changsha 410081, Hunan, Peoples R China
[5] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Guangdong, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2023年 / 478卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Ferroptosis; Cell death; Human body organ systems; Clinical treatment; REGULATED CELL-DEATH; HEPATOCELLULAR-CARCINOMA CELLS; GLUTATHIONE-PEROXIDASE; 4; ACUTE KIDNEY INJURY; LIPID-PEROXIDATION; LUNG-CANCER; PROMOTES FERROPTOSIS; INHIBITS FERROPTOSIS; PARKINSONS-DISEASE; OXIDATIVE STRESS;
D O I：
10.1007/s11010-023-04694-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Since ferroptosis was first described as an iron-dependent cell death pattern in 2012, there has been increasing interest in ferroptosis research. In view of the immense potential of ferroptosis in treatment efficacy and its rapid development in recent years, it is essential to track and summarize the latest research in this field. However, few writers have been able to draw on any systematic investigation into this field based on human body organ systems. Hence, in this review, we provide a comprehensive description of the latest progress in unveiling the roles and functions, as well as the therapeutic potential of ferroptosis, in treating diseases from the aspects of 11 human body organ systems (including the nervous system, respiratory system, digestive system, urinary system, reproductive system, integumentary system, skeletal system, immune system, cardiovascular system, muscular system, and endocrine system) in the hope of providing references for further understanding the pathogenesis of related diseases and bringing an innovative train of thought for reformative clinical treatment.
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页码：2695 / 2719
页数：25
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