Genomic Sequencing Profiles of Mycobacterium tuberculosis in Mandalay Region, Myanmar

被引：2

作者：

Phyu, Aye Nyein ^{[1
,2
]}

Aung, Si Thu ^{[3
]}

Palittapongarnpim, Prasit ^{[4
]}

Htet, Kyaw Ko Ko ^{[2
]}

Mahasirimongkol, Surakameth ^{[5
]}

Ruangchai, Wuthiwat ^{[4
]}

Jaemsai, Bharkbhoom ^{[4
]}

Aung, Htin Lin ^{[6
]}

Maung, Htet Myat Win ^{[2
]}

Chaiprasert, Angkana ^{[7
]}

Pungrassami, Petchawan ^{[8
]}

Chongsuvivatwong, Virasakdi ^{[2
]}

机构：

[1] Minist Hlth, Natl TB Programme, Dept Publ Hlth, Mandalay 05071, Myanmar

[2] Prince Songkla Univ, Fac Med, Dept Epidemiol, Hat Yai 90110, Thailand

[3] Minist Hlth, Dept Publ Hlth, Keng Tung 06231, Myanmar

[4] Mahidol Univ, Fac Sci, Pornchai Matangkasombut Ctr Microbial Genom, Dept Microbiol, Bangkok 10400, Thailand

[5] Minist Publ Hlth, Dept Med Sci, Med Life Sci Inst, Nonthaburi 11000, Thailand

[6] Univ Otago, Dept Microbiol & Immunol, Dunedin 9016, New Zealand

[7] Mahidol Univ, Siriraj Hosp, Fac Med, Off Res & Innovat, Bangkok 10700, Thailand

[8] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand

来源：

TROPICAL MEDICINE AND INFECTIOUS DISEASE | 2023年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

genomic sequencing profiles; Mycobacterium tuberculosis; Mandalay region; Myanmar; STREPTOMYCIN RESISTANCE; MUTATIONS; SPREAD;

D O I：

10.3390/tropicalmed8040239

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study aimed to characterize whole-genome sequencing (WGS) information of Mycobacterium tuberculosis (Mtb) in the Mandalay region of Myanmar. It was a cross-sectional study conducted with 151 Mtb isolates obtained from the fourth nationwide anti-tuberculosis (TB) drug-resistance survey. Frequency of lineages 1, 2, 3, and 4 were 55, 65, 9, and 22, respectively. The most common sublineage was L1.1.3.1 (n = 31). Respective multi-drug resistant tuberculosis (MDR-TB) frequencies were 1, 1, 0, and 0. Four clusters of 3 (L2), 2 (L4), 2 (L1), and 2 (L2) isolates defined by a 20-single-nucleotide variant (SNV) cutoff were detected. Simpson's index for sublineages was 0.0709. Such high diversity suggests that the area probably had imported Mtb from many geographical sources. Relatively few genetic clusters and MDR-TB suggest there is a chance the future control will succeed if it is carried out properly.

引用

页数：11

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