Anti-tumor immune potentiation targets-engineered nanobiotechnologies: Design principles and applications

被引：7
|
作者：
Jiao, Rong [1 ,2 ,3 ,4 ]
Lin, Xia [1 ,2 ,3 ,4 ]
Zhang, Qian [5 ]
Zhang, Yan [1 ,2 ,3 ,6 ,7 ]
Qin, Wen [1 ,2 ,3 ,4 ]
Yang, Qiaoling [1 ,2 ,3 ,4 ]
Xu, Chuan [1 ,2 ,3 ]
Chen, Fubo [1 ,2 ,3 ,6 ,7 ]
Zhang, Kun [1 ,2 ,3 ,4 ,7 ]
机构：
[1] Univ Elect Sci & Technol China, Dept Pharm, 32,First Ring Rd,West Sect 2, Chengdu 610072, Sichuan, Peoples R China
[2] Univ Elect Sci & Technol China, Dept Oncol, 32,First Ring Rd,West Sect 2, Chengdu 610072, Sichuan, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Sichuan Prov Peoples Hosp, Canc Inst, 32,First Ring Rd,West Sect 2, Chengdu 610072, Sichuan, Peoples R China
[4] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Guangxi Key Lab Biotargeting Theranost, 22 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China
[5] Ningxia Med Univ, Cardiovasc & Cerebrovascular Dis Hosp, Gen Hosp, Dept Ultrasound, 6 Ningan East Lane, Yinchuan, Ningxia, Peoples R China
[6] Tongji Univ, Dept Stomatol, 301 Yan chang zhong Rd, Shanghai 200072, Peoples R China
[7] Tongji Univ, Shanghai Peoples Hosp 10, Dept Med Ultrasound, 301 Yan chang zhong Rd, Shanghai 200072, Peoples R China
来源：
PROGRESS IN MATERIALS SCIENCE | 2024年 / 142卷
基金：
中国国家自然科学基金;
关键词：
TUMOR-ASSOCIATED MACROPHAGES; CANCER-ASSOCIATED FIBROBLASTS; BREAST-CANCER; IN-VIVO; INHIBIT MELANOMA; MYELOID CELLS; T-CELLS; NANOPARTICLES; MICROENVIRONMENT; IMMUNOTHERAPY;
D O I：
10.1016/j.pmatsci.2023.101230
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Combined therapeutic strategies hold promises in augmenting antigen release to enhance anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond that, specific nanobiotechnologies aimed at enhancing immune potency have made substantial progress. However, there have no focused reviews on it yet. Herein, we comprehensively outlined the latest cutting-edge breakthroughs in anti-tumor immunity potentiation-enabled nanobiotechnologies, e.g., those capable of capturing neoantigens or immune cells and homing to lymph nodes. Especially, we underlined the design concepts and immune enhancement rationales of these cutting-edge nanobiotechnologies with a highlight on targeting or engineering various immune cells, organs, targets, singling pathway, physiological activity or process as well as other tumor-related targets to activate or boost immune response, immune infiltration, or mitigate immunosuppressive tumor microenvironment. Finally, we provided distinctive insights into the challenges faced by these strategies and the research direction of clinical translation, and also the potential solutions were provided. We expect this review will give more inspirations to guide or aid to design emerging nanobiotechnologies objective to truthfully improving clinical immunotherapy and elevating and bringing clinical benefits to cancer-bearing patients.
引用
收藏
页数：31
相关论文
共 50 条
  • [21] POTENTIATION AND INHIBITION OF INTERFERON ACTION - ANTI-VIRAL AND ANTI-TUMOR STUDIES
    FLEISCHMANN, WR
    [J]. MEDICAL AND PEDIATRIC ONCOLOGY, 1981, 9 (01): : 89 - 92
  • [22] Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development
    Yuli Wang
    Xingyan Zhang
    Yuyan Wang
    Wenjing Zhao
    Huling Li
    Lixing Zhang
    Xinping Li
    Tiejun Zhang
    Hongbing Zhang
    He Huang
    Changxiao Liu
    [J]. Acta Pharmaceutica Sinica B, 2021, 11 (10) : 2957 - 2972
  • [23] DISSECTING THE ANTI-TUMOR IMMUNE RESPONSE IN GLIOBLASTOMA
    Chen, Dan
    [J]. NEURO-ONCOLOGY, 2019, 21 : 181 - 181
  • [24] Visualizing anti-tumor immune responses in vivo
    Perentes, Jean Y.
    Duda, Dan G.
    Jain, Rakesh K.
    [J]. DISEASE MODELS & MECHANISMS, 2009, 2 (3-4) : 107 - 110
  • [25] Role of Imiquimod in anti-tumor immune responses
    Drobits, B.
    Holcmann, M.
    Grundtner, R.
    Sibilia, M.
    [J]. WIENER KLINISCHE WOCHENSCHRIFT, 2008, 120 : 91 - 91
  • [26] Anti-tumor immune responses in human sarcomas
    Balachandran, V. P.
    Ocuin, L. M.
    Cavnar, M. J.
    Obaid, H.
    DeMatteo, R. P.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2010, 17 : S20 - S20
  • [27] Design Principles and Applications of Engineered Microbial Consortia
    Smith, R. P.
    [J]. INTERNATIONAL SYMPOSIUM ON BIOLOGICAL CONTROL OF POSTHARVEST DISEASES: CHALLENGES AND OPPORTUNITIES, 2011, 905 : 63 - 69
  • [28] Tumorigenesis and anti-tumor immune responses in Xenopus
    Goyos, Ana
    Robert, Jacques
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 167 - 176
  • [29] Trop molecules as targets for anti-tumor immunotherapy in man
    Alberti, S
    [J]. TUMORI JOURNAL, 2001, 87 (06): : S5 - S8
  • [30] Anti-tumor effects of crocetin and related molecular targets
    Moradzadeh, Maliheh
    Sadeghnia, Hamid Reza
    Tabarraei, Alijan
    Sahebkar, Amirhossein
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (03) : 2170 - 2182
12345