Anti-tumor immune potentiation targets-engineered nanobiotechnologies: Design principles and applications

被引：7
|
作者：
Jiao, Rong [1 ,2 ,3 ,4 ]
Lin, Xia [1 ,2 ,3 ,4 ]
Zhang, Qian [5 ]
Zhang, Yan [1 ,2 ,3 ,6 ,7 ]
Qin, Wen [1 ,2 ,3 ,4 ]
Yang, Qiaoling [1 ,2 ,3 ,4 ]
Xu, Chuan [1 ,2 ,3 ]
Chen, Fubo [1 ,2 ,3 ,6 ,7 ]
Zhang, Kun [1 ,2 ,3 ,4 ,7 ]
机构：
[1] Univ Elect Sci & Technol China, Dept Pharm, 32,First Ring Rd,West Sect 2, Chengdu 610072, Sichuan, Peoples R China
[2] Univ Elect Sci & Technol China, Dept Oncol, 32,First Ring Rd,West Sect 2, Chengdu 610072, Sichuan, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Sichuan Prov Peoples Hosp, Canc Inst, 32,First Ring Rd,West Sect 2, Chengdu 610072, Sichuan, Peoples R China
[4] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Guangxi Key Lab Biotargeting Theranost, 22 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China
[5] Ningxia Med Univ, Cardiovasc & Cerebrovascular Dis Hosp, Gen Hosp, Dept Ultrasound, 6 Ningan East Lane, Yinchuan, Ningxia, Peoples R China
[6] Tongji Univ, Dept Stomatol, 301 Yan chang zhong Rd, Shanghai 200072, Peoples R China
[7] Tongji Univ, Shanghai Peoples Hosp 10, Dept Med Ultrasound, 301 Yan chang zhong Rd, Shanghai 200072, Peoples R China
来源：
PROGRESS IN MATERIALS SCIENCE | 2024年 / 142卷
基金：
中国国家自然科学基金;
关键词：
TUMOR-ASSOCIATED MACROPHAGES; CANCER-ASSOCIATED FIBROBLASTS; BREAST-CANCER; IN-VIVO; INHIBIT MELANOMA; MYELOID CELLS; T-CELLS; NANOPARTICLES; MICROENVIRONMENT; IMMUNOTHERAPY;
D O I：
10.1016/j.pmatsci.2023.101230
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Combined therapeutic strategies hold promises in augmenting antigen release to enhance anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond that, specific nanobiotechnologies aimed at enhancing immune potency have made substantial progress. However, there have no focused reviews on it yet. Herein, we comprehensively outlined the latest cutting-edge breakthroughs in anti-tumor immunity potentiation-enabled nanobiotechnologies, e.g., those capable of capturing neoantigens or immune cells and homing to lymph nodes. Especially, we underlined the design concepts and immune enhancement rationales of these cutting-edge nanobiotechnologies with a highlight on targeting or engineering various immune cells, organs, targets, singling pathway, physiological activity or process as well as other tumor-related targets to activate or boost immune response, immune infiltration, or mitigate immunosuppressive tumor microenvironment. Finally, we provided distinctive insights into the challenges faced by these strategies and the research direction of clinical translation, and also the potential solutions were provided. We expect this review will give more inspirations to guide or aid to design emerging nanobiotechnologies objective to truthfully improving clinical immunotherapy and elevating and bringing clinical benefits to cancer-bearing patients.
引用
收藏
页数：31
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