Autonomic control of heart and vessels in patients with very early stage of Parkinson disease
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作者:
Oleksakova, J.
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Comenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Univ Hosp Martin, Kollarova 2, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Oleksakova, J.
[1
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Javorka, M.
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Comenius Univ, Jessenius Fac Med Martin, Dept Med Physiol, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Javorka, M.
[3
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Czippelova, B.
[3
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Mazgutova, N.
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机构:
Comenius Univ, Jessenius Fac Med Martin, Dept Med Physiol, Mala Hora 4, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Mazgutova, N.
[3
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Grofik, M.
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Comenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Univ Hosp Martin, Kollarova 2, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Grofik, M.
[1
,2
]
Babalova, L.
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Comenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Univ Hosp Martin, Kollarova 2, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Babalova, L.
[1
,2
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Skacik, P.
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Comenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Univ Hosp Martin, Kollarova 2, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Skacik, P.
[1
,2
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Kurca, E.
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Comenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Univ Hosp Martin, Kollarova 2, Martin 03601, SlovakiaComenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
Kurca, E.
[1
,2
]
机构:
[1] Comenius Univ, Jessenius Fac Med Martin, Clin Neurol, Kollarova 2, Martin 03601, Slovakia
[2] Univ Hosp Martin, Kollarova 2, Martin 03601, Slovakia
[3] Comenius Univ, Jessenius Fac Med Martin, Dept Med Physiol, Mala Hora 4, Martin 03601, Slovakia
Objective. Non-motor symptoms including those reflecting autonomic cardiovascular dysregulation are often present in Parkinson disease. It is unclear whether it is possible to detect cardiovascular autonomic dysregulation in the very early stage of Parkinson disease potentially supporting the concept of the upstream propagation of nervous system damage through autonomic nerves. We hypothesized that cardiovascular dysregulation should precede the motor symptoms and at the time of their occurrence autonomic dysregulation should be clearly demonstrable. Therefore, the aim of this study was to assess the various aspects of autonomic cardiovascular control in the very early stage of Parkinson disease. Approach. We performed prospective case-control study on 19 patients with Parkinson disease (<6 months after motor signs occurrence) and 19 healthy control subjects. For each phase of study protocol (supine, head-up tilt, supine recovery), we calculated a wide array of cardiovascular control related parameters reflecting cardiac chronotropic, cardiac inotropic and vasomotor control and baroreflex mediated cardiovascular response. Main results. We observed the well-preserved heart rate and blood pressure control in patients with early stage of Parkinson disease. However, causal analysis of interactions between heart rate and blood pressure oscillations revealed subtle differences in baroreflex function and baroreflex mediated vasoconstriction response to orthostasis. Furthermore, a tendency towards a decreased contraction strength in Parkinson disease was observed. Significance. Considering only subtle cardiovascular control impairment in our study employing a wide array of sensitive methods at the time when motor signs were clearly expressed, we suggest that motor signs dominated in this stage of Parkinson disease.
机构:
Catholic Univ Korea, Dept Internal Med, Div Gastroenterol, Seoul 137701, South Korea
Catholic Univ Korea, Ctr Hlth Promot, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Sung, Hye Young
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Kim, Joong-Seok
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Lee, Kwang-Soo
Kim, Yeong-In
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Catholic Univ Korea, Dept Neurol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Kim, Yeong-In
Song, In-Uk
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Catholic Univ Korea, Dept Neurol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Song, In-Uk
Chung, Sung-Woo
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Catholic Univ Korea, Dept Neurol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Chung, Sung-Woo
Yang, Dong-Won
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Catholic Univ Korea, Dept Neurol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Yang, Dong-Won
Cho, Yu Kyung
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Catholic Univ Korea, Dept Internal Med, Div Gastroenterol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Cho, Yu Kyung
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Park, Jae Myung
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Lee, In Seok
Kim, Sang Woo
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Catholic Univ Korea, Dept Internal Med, Div Gastroenterol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Kim, Sang Woo
Chung, In-Sik
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Catholic Univ Korea, Dept Internal Med, Div Gastroenterol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea
Chung, In-Sik
Choi, Myung-Gyu
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Catholic Univ Korea, Dept Internal Med, Div Gastroenterol, Seoul 137701, South KoreaCatholic Univ Korea, Dept Neurol, Seoul 137701, South Korea