Case report: Corticosteroid-resistant acute fibrinous and organizing pneumonia with myelodysplastic syndrome

被引:0
|
作者
Jiang, Dingyuan [1 ]
Chen, Xueying [1 ]
Li, Jun [1 ]
Zhao, Ling [2 ]
Dai, Huaping [1 ]
机构
[1] Chinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R China
[2] China Japan Friendship Hosp, Lab Dept Pathol, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
acute fibrinous and organizing pneumonia; myelodysplastic syndrome; fever of unknown origin; corticosteroid-resistant; interstitial lung disease; case report; pulmonary consolidation;
D O I
10.3389/fmed.2022.1047783
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute fibrinous and organizing pneumonia (AFOP) is a lung disease with an unusual pathological pattern. The definitive diagnosis of AFOP relies on pathological evidence of intra-alveolar fibrin exudate, lymphoplasmacytic infiltrate, and the absence of a hyaline membrane. Furthermore, its etiology is difficult to confirm, and corticosteroids are usually effective. Herein, we report the case of a young male who presented with high fever, hemocytopenia, and consolidation in both lungs. The initial misdiagnosis was community-acquired pneumonia. Subsequently, a lung biopsy revealed abundant fibrin and fibroblast exudates in the alveolar spaces, indicating AFOP. In addition, bone marrow biopsy and karyotype analysis demonstrated that the patient simultaneously had myelodysplastic syndrome (MDS) and hemophagocytic lymphohistiocytosis. In this case, the AFOP was considered secondary to MDS; however, the disease did not respond to glucocorticoid treatment or chemotherapy. Hence, AFOP should be considered in patients with underlying hematological diseases, and early identification and diagnosis are important. Furthermore, the management of patients with severe AFOP requires further investigation.
引用
收藏
页数:6
相关论文
共 50 条
  • [31] Acute fibrinous and organizing pneumonia in a patient with Sjögren’s syndrome and Legionella pneumonia: a case report and literature review
    Ye Lu
    Wei Zheng
    Wei Cao
    Xianghong Yang
    Li Zhao
    Yu Chen
    BMC Pulmonary Medicine, 22
  • [32] A case report of acute fibrinous and organizing pneumonia with pneumothorax and avian exposure history
    Chiu, Kam Yu
    Li, Jian Guo
    Gu, Ying Ying
    CLINICAL RESPIRATORY JOURNAL, 2018, 12 (02): : 811 - 815
  • [33] Successful Lung Retransplantation in a Patient With Acute Fibrinous and Organizing Pneumonia: A Case Report
    Renaud-Picard, B.
    Degot, T.
    Biondini, D.
    Weingertner, N.
    Reeb, J.
    Chenard, M. P.
    Kessler, R.
    TRANSPLANTATION PROCEEDINGS, 2015, 47 (01) : 182 - 185
  • [34] A Case of Acute Fibrinous and Organizing Pneumonia Associated with Vaping
    Liu, K.
    Wu, C.
    Li, Y.
    Choi, H.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [35] Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome
    Kang, Hyo Jae
    Choi, Sun Mi
    Jeong, Yun Jeong
    Park, Jong Sun
    Lee, Sei Won
    Yoon, Ho Il
    Lee, Jae Ho
    Lee, Choon-Tack
    Cho, Young-Jae
    TUBERCULOSIS AND RESPIRATORY DISEASES, 2011, 71 (05) : 368 - 372
  • [36] Is Acute Fibrinous and Organizing Pneumonia the mirror of an immune dysregulatory syndrome?
    Labarinas, S.
    Rougemont, A.
    Pache, J.
    Rochat, I.
    Barazzone, C.
    Caliera, M. Tempia
    Belli, D.
    Passweg, J.
    Ozsahin, H.
    Ansari, M.
    SWISS MEDICAL WEEKLY, 2010, 140 (21-22) : 26S - 26S
  • [37] Acute fibrinous and organizing pneumonia: a new entity of organizing pneumonia
    Chorti, M.
    HISTOPATHOLOGY, 2010, 57 : 229 - 229
  • [38] Acute fibrinous and organizing pneumonia as initial presentation of primary Sjogren's syndrome: a case report and literature review
    Wang, Yukai
    Zhao, Shucan
    Du, Guangzhou
    Ma, Songkun
    Lin, Qisheng
    Lin, Jianqun
    Zheng, Kedi
    Zhang, Guohong
    Matucci-Cerinic, Marco
    CLINICAL RHEUMATOLOGY, 2018, 37 (07) : 2001 - 2005
  • [39] Acute Fibrinous and Organizing Pneumonia (AFOP) Associated with Chemotherapy Drug Reaction: A Case Report
    Cerezoli, M.
    Soares, M. R.
    Tibana, R. C.
    Fukuda, C. Y.
    Pereira, C. A. D. C.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [40] AN IDIOPATHIC ACUTE FIBRINOUS ORGANIZING PNEUMONIA
    Reddy, R. M.
    Porres-Aquilar, M.
    Harris, E.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181