Case report: Corticosteroid-resistant acute fibrinous and organizing pneumonia with myelodysplastic syndrome
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作者:
Jiang, Dingyuan
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Chinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R ChinaChinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R China
Jiang, Dingyuan
[1
]
Chen, Xueying
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Chinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R ChinaChinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R China
Chen, Xueying
[1
]
Li, Jun
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Chinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R ChinaChinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R China
Li, Jun
[1
]
Zhao, Ling
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China Japan Friendship Hosp, Lab Dept Pathol, Beijing, Peoples R ChinaChinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R China
Zhao, Ling
[2
]
Dai, Huaping
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Chinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R ChinaChinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R China
Dai, Huaping
[1
]
机构:
[1] Chinese Acad Med Sci, China Japan Friendship Hosp, Inst Resp Med, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis,Dept, Beijing, Peoples R China
[2] China Japan Friendship Hosp, Lab Dept Pathol, Beijing, Peoples R China
acute fibrinous and organizing pneumonia;
myelodysplastic syndrome;
fever of unknown origin;
corticosteroid-resistant;
interstitial lung disease;
case report;
pulmonary consolidation;
D O I:
10.3389/fmed.2022.1047783
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Acute fibrinous and organizing pneumonia (AFOP) is a lung disease with an unusual pathological pattern. The definitive diagnosis of AFOP relies on pathological evidence of intra-alveolar fibrin exudate, lymphoplasmacytic infiltrate, and the absence of a hyaline membrane. Furthermore, its etiology is difficult to confirm, and corticosteroids are usually effective. Herein, we report the case of a young male who presented with high fever, hemocytopenia, and consolidation in both lungs. The initial misdiagnosis was community-acquired pneumonia. Subsequently, a lung biopsy revealed abundant fibrin and fibroblast exudates in the alveolar spaces, indicating AFOP. In addition, bone marrow biopsy and karyotype analysis demonstrated that the patient simultaneously had myelodysplastic syndrome (MDS) and hemophagocytic lymphohistiocytosis. In this case, the AFOP was considered secondary to MDS; however, the disease did not respond to glucocorticoid treatment or chemotherapy. Hence, AFOP should be considered in patients with underlying hematological diseases, and early identification and diagnosis are important. Furthermore, the management of patients with severe AFOP requires further investigation.
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Resp Med, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Resp Med, Guangzhou, Guangdong, Peoples R China
Li, Jian Guo
Gu, Ying Ying
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机构:
Guangzhou Med Collage, Dept Pathol, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Resp Med, Guangzhou, Guangdong, Peoples R China
机构:
Seoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Seoul Natl Univ, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Kang, Hyo Jae
Choi, Sun Mi
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Seoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Seoul Natl Univ, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Choi, Sun Mi
Jeong, Yun Jeong
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机构:
Seoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Seoul Natl Univ, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Jeong, Yun Jeong
Park, Jong Sun
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机构:
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Gumi Dong, Seoul 463707, South Korea
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Park, Jong Sun
Lee, Sei Won
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机构:
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Gumi Dong, Seoul 463707, South Korea
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Lee, Sei Won
Yoon, Ho Il
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机构:
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Gumi Dong, Seoul 463707, South Korea
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Yoon, Ho Il
Lee, Jae Ho
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机构:
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Gumi Dong, Seoul 463707, South Korea
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Lee, Jae Ho
Lee, Choon-Tack
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机构:
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Gumi Dong, Seoul 463707, South Korea
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Lee, Choon-Tack
Cho, Young-Jae
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机构:
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Gumi Dong, Seoul 463707, South Korea
Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Lung Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea