Ertapenem plus meropenem combination treatment in carbapenem-resistant Klebsiella pneumoniae bacteremia: an analysis of 53 cases

被引：0

作者：

Onal, Ugur ^{[1
,2
]}

Akyol, Deniz ^{[1
,3
]}

Kaya, Arda ^{[1
]}

Baskol, Dilsah ^{[1
]}

Kenanoglu, Buse ^{[1
]}

Sanlidag, Gamze ^{[1
]}

Onal, Ayse Uyan ^{[1
,4
]}

Avsar, Cansu Bulut ^{[1
,5
]}

Mert, Merve ^{[1
]}

Memetali, Seichan ^{[1
]}

Erdem, Hueseyin Aytac ^{[1
]}

Bozkurt, Devrim ^{[6
]}

Simsir, Adnan ^{[7
]}

Bozbiyik, Osman ^{[8
]}

Kahraman, Umit ^{[9
]}

Ozgiray, Erkin ^{[10
]}

Korkmaz, Pervin ^{[11
]}

Cilli, Feriha ^{[12
]}

Pullukcu, Husnu ^{[1
]}

Yamazhan, Tansu ^{[1
]}

Tasbakan, Meltem Isikgoz ^{[1
]}

Arda, Bilgin ^{[1
]}

Ulusoy, Sercan ^{[1
]}

Sipahi, Oguz Resat ^{[1
,13
]}

机构：

[1] Ege Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkiye

[2] Uludag Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkiye

[3] Kagizman State Hosp, Infect Dis Clin, Kars, Turkiye

[4] Yuksek Ihtisas Teaching & Res Hosp, Dept Urol, Bursa, Turkiye

[5] Bakircay Univ, Cigli Teaching & Res Hosp, Izmir, Turkiye

[6] Ege Univ, Fac Med, Dept Internal Med, Izmir, Turkiye

[7] Ege Univ, Fac Med, Dept Urol, Izmir, Turkiye

[8] Ege Univ, Fac Med, Dept Gen Surg, Izmir, Turkiye

[9] Ege Univ, Fac Med, Dept Cardiovasc Surg, Izmir, Turkiye

[10] Ege Univ, Fac Med, Dept Neurosurg, Izmir, Turkiye

[11] Ege Univ, Fac Med, Dept Chest Dis, Izmir, Turkiye

[12] Ege Univ, Fac Med, Dept Med Microbiol, Izmir, Turkiye

[13] King Hamad Univ Hosp, Bahrain Oncol Ctr, Infect Dis Dept, Muharraq, Bahrain

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2023年 / 42卷 / 10期

关键词：

Double carbapenem therapy; Carbapenem-resistant Klebsiella pneumonia; Bacteremia; THERAPY; INFECTIONS;

D O I：

10.1007/s10096-023-04660-3

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Herein, we aimed to describe the outcomes of patients with blood stream infections due to carbapenem-resistant Klebsiella pneumoniae (CR-Kp) who received ertapenem plus meropenem combination treatment (EMCT). A total of 53 patients with culture proven CR-Kp bacteremia treated with ertapenem + meropenem were included. The patients with secondary bacteremia due to urinary tract infection exhibited a significantly lower 1-month mortality (OMM), particularly in those with microbiological eradication and those with end-of-treatment success. Salvage EMCT resulted in 49% 1-month survival.

引用

页码：1269 / 1273

页数：5

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