This paper addresses the problem of adaptive tracking control of high-order nonlinear systems with time-varying delays under asymmetric output constraints. Unlike the existing researches, the studied system exhibits constantly changing unknown powers, which makes the existing Lyapunov Functionals invalid. Therefore, the Lyapunov Functionals are carefully designed to be suitable for the changing powers, where the changing powers include low power (0 < p(i )<= 1 ) and high (p(i )<( )1). Besides, we also incorporate the well-constructed dynamic gain signals into the Lyapunov Functionals to enhance the robustness, accuracy, and response speed of the system. Further, we cleverly deal with the time-varying delays by combining the novel dynamic gain signals and Lyapunov-Krasovskii (L-K) Functionals in the controller design process. For the system performance requirement, the asymmetric output constraints are considered by introducing a nonlinear transformation for the output signal x(1) and the reference signal y(r) . While the derivative of this nonlinear transformation generates a gain term in the form of function, which makes the controller design more difficult. We utilize the adding one power integrator technique to design the desired controller and solve the design difficulty caused by the gain term. Under the proposed controller, all the signals in the closed-loop system remain bounded, the asymmetric output constraints are not violated as well as the tracking error stays in a small neighborhood of the origin. Finally, a simulation example is given to demonstrate the effectiveness of the present strategy.