Evidence-Based Approach of Biologic Therapy in Bronchial Asthma

被引：1

作者：

Liaqat, Adnan ^{[1
]}

Mason, Mathew ^{[2
]}

Foster, Brian ^{[3
]}

Gregory, Grant ^{[4
]}

Patel, Avani ^{[5
]}

Barlas, Aisha ^{[6
]}

Kulkarni, Sagar ^{[7
]}

Basso, Rafaela ^{[7
]}

Patak, Pooja ^{[8
]}

Liaqat, Hamza ^{[9
]}

Qureshi, Muhammad ^{[7
]}

Shehata, Abdelrahman ^{[7
]}

Awad, Yousef ^{[7
]}

Ghaly, Mina ^{[7
]}

Gulzar, Qamar ^{[7
]}

Doty, Walter ^{[7
]}

机构：

[1] McLaren Hlth Michigan State Univ, Pulm & Crit Care Med, Flint, MI 48532 USA

[2] Baylor Coll Med, Internal Med, Houston, TX 77030 USA

[3] Cleveland Clin Florida, Pulm & Crit Care Med, Weston, FL 33321 USA

[4] Alabama Coll Osteopath Med, Internal Med, Dothan, AL 36303 USA

[5] Meharry Med Coll, Internal Med, Nashville, TN 37208 USA

[6] Mercy Hlth, Internal Med, Rockford, IL 61114 USA

[7] Southeast Hlth, Pulm & Crit Care Med, Dothan, AL 36301 USA

[8] Univ Missouri, Pulm & Crit Care Med, Kansas City, MO 64110 USA

[9] Wah Med Coll, Internal Med, Wah Cantt 47040, Pakistan

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 13期

关键词：

asthma; omalizumab; reslizumab; benralizumab; mepolizumab; dupilumab; tezepelumab; SEVERE EOSINOPHILIC ASTHMA; THYMIC STROMAL LYMPHOPOIETIN; DOUBLE-BLIND; INHALED CORTICOSTEROIDS; PERSISTENT ASTHMA; MEPOLIZUMAB; PLACEBO; TEZEPELUMAB; OMALIZUMAB; SAFETY;

D O I：

10.3390/jcm12134321

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The emergence of biologic agents in the treatment of bronchial asthma has a wide impact on improving quality of life, reducing morbidity, and overall health care utilization. These therapies usually work by targeting specific inflammatory pathways involving type 2 inflammation and are particularly effective in severe eosinophilic asthma. Various randomized controlled trials have shown their effectiveness by reducing exacerbation rates and decreasing required glucocorticoid dosages. One of the relatively newer agents, tezepelumab, targets thymic stromal lymphoprotein and has proven its efficacy in patients independent of asthma phenotype and serum biomarker levels. This article reviews the pathophysiologic mechanism behind biologic therapy and offers an evidence-based discussion related to the indication, benefits, and adverse effects of such therapies.

引用

页数：12

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