S100 Protein Expression in Primary and Metastatic Neuroendocrine Neoplasms

被引:2
|
作者
Pepper, Michael A. [1 ]
Dulken, Ben W. [1 ]
Wang, Yiwen [1 ]
Zemek, Allison J. [2 ]
Martin, Brock A. [1 ,3 ]
Charu, Vivek [1 ]
Longacre, Teri A. [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA USA
[2] Southern Calif Permanente Med Grp, Dept Pathol, Downey, CA USA
[3] Univ Louisville, Sch Med, Dept Pathol & Lab Med, Louisville, KY USA
关键词
well-differentiated neuroendocrine tumor; neuroendocrine carcinoma; S100; pancreatic neuroendocrine tumor; PANCREATIC ENDOCRINE; IMMUNOHISTOCHEMICAL PANEL; TUMORS; TTF-1; PDX-1; DISTINCTION; NESP-55; NESP55; CDX-2;
D O I
10.1097/PAS.0000000000002154
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Neuroendocrine neoplasms can arise in a wide variety of anatomic sites including the gastrointestinal tract, pancreas, and lung, among others. Here, we report on the expression of S100 protein in a tissue microarray composed of 919 distinct primary and metastatic neuroendocrine neoplasms from 548 patients. S100 protein is a commonly used marker in many laboratories for the identification of neural and melanocytic neoplasms and occasionally used in the workup for neuroendocrine neoplasms when the diagnosis of paraganglioma is being considered. We show that strong S100 protein expression is highly specific to well-differentiated neuroendocrine tumors of pancreatic origin. This finding suggests potential diagnostic utility of this marker in cases of tumors of unknown origin, and emphasizes that S100 protein expression should not be an unexpected finding in neuroendocrine tumors of pancreatic origin.
引用
收藏
页码:157 / 162
页数:6
相关论文
共 50 条
  • [31] Unusual expression of S-100 protein in histiocytic neoplasms
    Tomaszewski, MM
    Lupton, GP
    JOURNAL OF CUTANEOUS PATHOLOGY, 1998, 25 (03) : 129 - 135
  • [32] Prognostic value of protein S100 expression in gastrointestinal stromal tumor
    Perez, D.
    Demartines, N.
    Jaeger, D.
    Clavien, P.
    BRITISH JOURNAL OF SURGERY, 2006, 93 (09) : 1175 - 1175
  • [33] Calbindin and S100 Protein Expression in the Developing Inner Ear in Mice
    Buckiova, Daniela
    Syka, Josef
    JOURNAL OF COMPARATIVE NEUROLOGY, 2009, 513 (05) : 469 - 482
  • [34] Unique Metastatic Patterns in Neuroendocrine Neoplasms of Different Primary Origin
    Hermans, B.
    Derks, J.
    Willems, A.
    Bilochvostenko, M.
    Bayazit, S.
    Speel, E. J.
    Dercksen, W.
    de Vos-Geelen, J.
    Dingemans, A. M.
    NEUROENDOCRINOLOGY, 2020, 110 : 81 - 81
  • [35] Unique Metastatic Patterns in Neuroendocrine Neoplasms of Different Primary Origin
    Hermans, Bregtje C. M.
    de Vos-Geelen, Judith
    Derks, Jules L.
    Latten, Loes
    Liem, Ing Han
    van der Zwan, Jan Maarten
    Speel, Ernst-Jan M.
    Dercksen, M. Wouter
    Dingemans, Anne-Marie C.
    NEUROENDOCRINOLOGY, 2021, 111 (11) : 1111 - 1120
  • [36] Expression of S100 protein subtypes in desmoplastic melanoma, neurofibroma and schwannoma
    Chiriboga, L.
    Yee, H.
    Nonaka, D.
    MODERN PATHOLOGY, 2007, 20 : 91A - 92A
  • [37] Expression of S100 protein family members in the pathogenesis of bladder tumors
    Yao, Ruisheng
    Lopez-Beltran, Antonio
    Maclennan, Gregory T.
    Montironi, Rodolfo
    Eble, John N.
    Cheng, Liang
    ANTICANCER RESEARCH, 2007, 27 (5A) : 3051 - 3058
  • [38] Expression of S100 protein subtypes in desmoplastic melanoma, neurofibroma and schwannoma
    Chiriboga, L.
    Yee, H.
    Nonaka, D.
    LABORATORY INVESTIGATION, 2007, 87 : 91A - 92A
  • [39] S100 and cytokine expression in caries
    McLachlan, JL
    Sloan, AJ
    Smith, AJ
    Landini, G
    Cooper, PR
    INFECTION AND IMMUNITY, 2004, 72 (07) : 4102 - 4108
  • [40] S100 PROTEIN EXPRESSION IN SUBPOPULATIONS OF NEURONS OF RAT-BRAIN
    RICKMANN, M
    WOLFF, JR
    NEUROSCIENCE, 1995, 67 (04) : 977 - 991