Amperometric Method for Detecting Paracetamol using a Carbon Paste Electrode Modified with Vanadium(V) Oxide

被引：3

作者：

Nagles, Edgar ^{[1
]}

Cardenas-Riojas, Andy A. ^{[2
]}

Anaya-Roa, Fernando ^{[1
]}

Roldan-Tello, Luz ^{[1
]}

Hurtado, John J. ^{[3
]}

机构：

[1] Univ Nacl Mayor San Marcos, Fac Quim & Ing Quim, Lima 15081, Peru

[2] Univ Nacl Ingn, Fac Ciencias, Lab Electroquim Aplicada, Ave Tupac Amaru 210, Rimac 15333, Lima, Peru

[3] Univ Los Andes, Dept Quim, Bogota 111711, Colombia

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 06期

关键词：

Paracetamol; vanadium oxide (V); Carbon paste; Modified electrode; ELECTROCHEMICAL DETERMINATION; ACETAMINOPHEN; NANOPARTICLES;

D O I：

10.1002/slct.202304770

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This new and simple amperometric method takes advantage of the electroactivity of V2O5 in the oxidation of paracetamol (PCM) on a carbon paste electrode (CPE). With the modified electrode (VOX/CPE) the anode peak current for PCM was more than 100 % than that of the unmodified electrode. The electrode surface was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). The amperograms were measured at +0.70 V (vs Ag/AgCl), and the calibration curve indicated a detection limit of 0.06 mu mol/L and a sensitivity of 1.93 mu A/mu M cm2. The modified electrode was used in the detection of solid drugs such as PCM tablets and children's syrup with acceptable results. A novel amperometric method is reported for the detection of paracetamol using a carbon paste decorated with vanadium oxide. This method provided a detection limit less than 1.0 mu mol/L. The results for this new method are interesting due to its potential for application in the pharmaceutical industry. image

引用

页数：8

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