H3K36 methylation is a reprogramming barrier

被引：1

作者：

Cohen, Lea Rachel Zehava ^{[1
,2
]}

Meshorer, Eran ^{[1
,2
]}

机构：

[1] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Genet, Jerusalem, Israel

来源：

NATURE CELL BIOLOGY | 2023年 / 25卷 / 08期

关键词：

PLASTICITY;

D O I：

10.1038/s41556-023-01147-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reprogramming of somatic cells is an inherently inefficient process. A new study has now identified histone H3K36 methylation as a crucial reprogramming barrier that operates downstream of TGF beta signalling. Global inhibition of H3K36 methylation induced PRC2-dependent silencing of mesenchymal genes and dramatically increased reprogramming efficiency.

引用

页码：1077 / 1078

页数：2

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