H3K36 methylation is a reprogramming barrier

被引：1
|
作者：
Cohen, Lea Rachel Zehava [1 ,2 ]
Meshorer, Eran [1 ,2 ]
机构：
[1] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Genet, Jerusalem, Israel
来源：
NATURE CELL BIOLOGY | 2023年 / 25卷 / 08期
关键词：
PLASTICITY;
D O I：
10.1038/s41556-023-01147-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Reprogramming of somatic cells is an inherently inefficient process. A new study has now identified histone H3K36 methylation as a crucial reprogramming barrier that operates downstream of TGF beta signalling. Global inhibition of H3K36 methylation induced PRC2-dependent silencing of mesenchymal genes and dramatically increased reprogramming efficiency.
引用
收藏
页码：1077 / 1078
页数：2
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