Modular Synthesis of 1,2-Benzothiazines and 1,2-Benzothiazine 1-Imines via Palladium-Catalyzed C-H/C-C Activation Reactions

被引：2

作者：

Ren, Yifan ^{[1
]}

Mo, Lisha ^{[1
]}

Wang, Yali ^{[1
]}

Yu, Limin ^{[1
]}

Yin, Minhai ^{[1
]}

Xiong, Zhuang ^{[2
]}

Teng, Fan ^{[3
]}

He, Yimiao ^{[1
]}

机构：

[1] Nanning Normal Univ, Coll Chem & Mat, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China

[2] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

[3] Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 05期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE ANNULATION; H FUNCTIONALIZATION; SULFOXIMINES; SULFONDIIMINES; ACIDS;

D O I：

10.1021/acs.joc.3c02799

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, a modular approach toward cyclic sulfoximines and sulfondiimines via palladium-catalyzed intramolecular C-H/C-C activation reactions was reported. Various 1,2-benzothiazines including bicyclic, tricyclic, highly fused ones, ones of the seven-membered ring, along with 1,2-benzothiazine 1-imines were accessed in good yields. KIE experiment demonstrated that the C-H bond cleavage at the position ortho to the sulfoximine group is not the rate-determining step in the coupling reaction.

引用

页码：3345 / 3358

页数：14

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