Determinants of Hypoglycemia in Premature Vietnamese Infants: A Case-Control Study

被引:0
|
作者
Nguyen, Rang N. [1 ]
Tran, Tuong M. [1 ]
Le, Ly Lien H. [2 ]
Ton, Chanh Q. [2 ]
机构
[1] Can Tho Univ Med & Pharm, Dept Pediat, Can Tho, Vietnam
[2] Women & Children Hosp Giang, Dept Pediat, An Giang, Vietnam
关键词
premature infants; gestational hypertension; gestational weight gain; gestational diabetes; neonatal hypoglycemia; GESTATIONAL DIABETES-MELLITUS; WEIGHT-GAIN; NEONATAL HYPOGLYCEMIA; ASSOCIATION; MACROSOMIA; RISK;
D O I
10.7759/cureus.52905
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Premature infants are more likely to experience hypoglycemia. Early recognition and prompt therapy are essential to avoiding neurological sequelae in the future. This study aimed to identify the determinants of hypoglycemia in premature Vietnamese infants. Methodology This was a case -control study conducted at the Neonatal Intensive Care Unit, The Women and Children Hospital of An Giang, Vietnam. Hypoglycemia was defined as a plasma glucose value of less than 2.6 mmol/L (47 mg/dL) after two hours postpartum. Maternal and neonatal information was collected and analyzed. Both bivariate and multiple logistic regression models were used to identify the risk factors of neonatal hypoglycemia (NH) Results A total of 65 cases and 195 controls were included in the study. Gestational diabetes mellitus (GDM) (adjusted odds ratio [AOR] 3.78, 95% confidence interval [CI] 1.69-8.52; P < 0.001) and excessive gestational weight gain (GWG) (AOR 2.80, 95% CI 1.12-6.98; P < 0.026) were associated with NH in the multiple logistic regression model. An observed positive interaction between gestational hypertension and GDM on NH yielded an odds ratio (OR) of 6.29 (95% CI 2.46-16.64). Conclusions GDM, excessive GWG, and the interaction between gestational hypertension and GDM were the determinants of hypoglycemia in premature infants.
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页数:9
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