A Facile, Mechanochemical, Solvent-, and Catalyst-Free Synthesis of Functionalized 4-Thiazolidinones

被引：1
|
作者：
Wahan, Simranpreet K. [1 ]
Chawla, Pooja A. [2 ]
Singh, Parvesh [3 ]
Kumar, Rupesh [1 ]
Bhargava, Gaurav [1 ]
机构：
[1] IK Gujral Punjab Tech Univ, Dept Chem Sci, Kapurthala, Punjab, India
[2] ISF Coll Pharm, Dept Pharmaceut Chem, Moga, Punjab, India
[3] Univ KwaZulu Natal, Sch Chem & Phys, Durban, South Africa
来源：
SYNOPEN | 2023年 / 07卷 / 04期
关键词：
mechanochemistry; green chemistry; grinding; 4-thiazolidinones; solvent-free synthesis; ONE-POT SYNTHESIS; BIOLOGICAL-ACTIVITY; THIAZOLIDINONES; EFFICIENT; CHEMISTRY; AGENTS;
D O I：
10.1055/a-2190-9678
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly eco-friendly greener approach based on the mech-anochemical method using mortar and pestle is explored for the prepa-ration of a variety of functionalized 4-thiazolidinones. The developedmethodology does not require the use of harmful or expensive reagentsand organic solvents and requires very less reaction time with easy iso-lation. The explored greener approach for the synthesis of 4-thiazolidi-nones is an important in terms of their usefulness for their valuablepharmacological properties.
引用
收藏
页码：615 / 618
页数：4
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