Maternal Serum Vitamin B12 during Pregnancy and Offspring Autism Spectrum Disorder

被引：2
|
作者：
Sourander, Andre [1 ,2 ]
Silwal, Sanju [1 ]
Surcel, Helja-Marja [3 ,4 ]
Hinkka-Yli-Salomaki, Susanna [1 ]
Upadhyaya, Subina [1 ]
McKeague, Ian W. [5 ]
Cheslack-Postava, Keely [6 ]
Brown, Alan S. [6 ,7 ]
机构：
[1] Univ Turku, Res Ctr Child Psychiat, INVEST Flagship, Turku 20014, Finland
[2] Turku Univ Hosp, Dept Child Psychiat, Turku 20521, Finland
[3] Univ Oulu, Fac Med, Oulu 90014, Finland
[4] Oulu Univ Hosp, Biobank Borealis Northern Finland, Oulu 90014, Finland
[5] Columbia Univ, Dept Biostat, Mailman Sch Publ Hlth, New York, NY 10032 USA
[6] Columbia Univ, New York State Psychiat Inst, Dept Psychiat, Irving Med Ctr, New York, NY 10032 USA
[7] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10032 USA
来源：
NUTRIENTS | 2023年 / 15卷 / 08期
基金：
芬兰科学院; 美国国家卫生研究院;
关键词：
maternal vitamin B12; autism spectrum disorder; ASD; maternal; prenatal; FOLIC-ACID; FOLATE CONCENTRATIONS; INSULIN-RESISTANCE; RISK; DEFICIENCY; BIRTH; HOMOCYSTEINE; ASSOCIATION; SUPPLEMENTS;
D O I：
10.3390/nu15082009
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
This study examined the association between maternal serum vitamin B12 levels during early pregnancy and offspring autism spectrum disorders (ASD) and subtypes. Based on a Finnish national birth cohort, case offspring (n = 1558) born in 1987-2007 and diagnosed with ASD by 2015 were matched with one control on date of birth, sex and place of birth. Maternal vitamin B12 levels were measured during first and early second trimesters of pregnancy. High maternal vitamin B12 levels (>= 81th percentile) was associated with increased risk for offspring childhood autism, adjusted odds ratio, 1.59, 95% confidence interval 1.06-2.41 (p = 0.026). No significant associations were observed between maternal vitamin B12 levels and offspring Asperger's or pervasive developmental disorder/NOS.
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页数：13
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