Persistence of Anti-S1 IgG against SARS-CoV-2 Eight Months after the Booster Dose of Vaccine in Naive and Previously Infected Healthcare Workers

被引:2
|
作者
Algarate, Sonia [1 ,2 ,3 ]
Serrano, Laura [1 ,3 ]
Bueno, Jessica [1 ,2 ]
Herrero-Cortina, Beatriz [1 ,3 ,4 ]
Alvarado, Elena [1 ]
Gonzalez-Barriga, Maria T. [1 ,3 ]
Ducons, Maria [1 ]
Montero-Marco, Jesica [1 ,3 ]
Arnal, Sara [1 ]
Acha, Beatriz [1 ,3 ]
Riesgo, Maria [1 ]
Taboada, Ana [1 ,3 ]
Sanz-Burillo, Pilar [1 ,3 ]
Yuste, Cristina [1 ,3 ]
Benito, Rafael [1 ,2 ,3 ]
机构
[1] Hosp Clin Univ Lozano Blesa Zaragoza, Ave San Juan Bosco 15, Zaragoza 50009, Spain
[2] Univ Zaragoza, Microbiol Dept, Calle Pedro Cerbuna 12, Zaragoza 50009, Spain
[3] Inst Invest Sanitaria Aragon, Ave San Juan Bosco 13, Zaragoza 50009, Spain
[4] Univ San Jorge, Nursing Dept, Autovia Mudejar,Km 299, Zaragoza 50830, Spain
关键词
SARS-CoV-2; booster vaccine; post-vaccine IgG antibody persistence;
D O I
10.3390/ijms241310713
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Our aim was to evaluate the immune response of healthcare workers included in the RIPOVAC study, after receiving a booster dose (third dose), in terms of intensity and persistence of induced antibodies. In the second phase of the RIPOVAC study, between December 2021 and January 2022, eight months after the second dose, 389 voluntary, immunocompetent, non-pregnant healthcare workers received a booster dose of SARS-CoV-2 vaccine, and a serum sample was obtained. Two groups of patients were established: with and without previous SARS-CoV-2 infection. In order to quantify anti-S1 IgG (AU/mL) we used CMIA (Abbott). All of the health workers were anti-S IgG positive 8 months after receiving the booster dose of the vaccine, with a mean of 17,040 AU/mL. In 53 patients without previous infection, antibody levels increased by a mean of 10,762 AU/mL. This figure is seven times higher than the one produced after the second dose (1506 AU/mL). The booster dose produces a robust elevation of the antibody level, which persists at 8 months, with levels significantly higher than those reached after the second dose, which allow one to predict a persistence of more than one year. The study demonstrates the efficacy of the booster dose of anti-SARS-CoV-2 vaccines.
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页数:7
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