Persistence of Anti-S1 IgG against SARS-CoV-2 Eight Months after the Booster Dose of Vaccine in Naive and Previously Infected Healthcare Workers

被引:2
|
作者
Algarate, Sonia [1 ,2 ,3 ]
Serrano, Laura [1 ,3 ]
Bueno, Jessica [1 ,2 ]
Herrero-Cortina, Beatriz [1 ,3 ,4 ]
Alvarado, Elena [1 ]
Gonzalez-Barriga, Maria T. [1 ,3 ]
Ducons, Maria [1 ]
Montero-Marco, Jesica [1 ,3 ]
Arnal, Sara [1 ]
Acha, Beatriz [1 ,3 ]
Riesgo, Maria [1 ]
Taboada, Ana [1 ,3 ]
Sanz-Burillo, Pilar [1 ,3 ]
Yuste, Cristina [1 ,3 ]
Benito, Rafael [1 ,2 ,3 ]
机构
[1] Hosp Clin Univ Lozano Blesa Zaragoza, Ave San Juan Bosco 15, Zaragoza 50009, Spain
[2] Univ Zaragoza, Microbiol Dept, Calle Pedro Cerbuna 12, Zaragoza 50009, Spain
[3] Inst Invest Sanitaria Aragon, Ave San Juan Bosco 13, Zaragoza 50009, Spain
[4] Univ San Jorge, Nursing Dept, Autovia Mudejar,Km 299, Zaragoza 50830, Spain
关键词
SARS-CoV-2; booster vaccine; post-vaccine IgG antibody persistence;
D O I
10.3390/ijms241310713
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Our aim was to evaluate the immune response of healthcare workers included in the RIPOVAC study, after receiving a booster dose (third dose), in terms of intensity and persistence of induced antibodies. In the second phase of the RIPOVAC study, between December 2021 and January 2022, eight months after the second dose, 389 voluntary, immunocompetent, non-pregnant healthcare workers received a booster dose of SARS-CoV-2 vaccine, and a serum sample was obtained. Two groups of patients were established: with and without previous SARS-CoV-2 infection. In order to quantify anti-S1 IgG (AU/mL) we used CMIA (Abbott). All of the health workers were anti-S IgG positive 8 months after receiving the booster dose of the vaccine, with a mean of 17,040 AU/mL. In 53 patients without previous infection, antibody levels increased by a mean of 10,762 AU/mL. This figure is seven times higher than the one produced after the second dose (1506 AU/mL). The booster dose produces a robust elevation of the antibody level, which persists at 8 months, with levels significantly higher than those reached after the second dose, which allow one to predict a persistence of more than one year. The study demonstrates the efficacy of the booster dose of anti-SARS-CoV-2 vaccines.
引用
收藏
页数:7
相关论文
共 50 条
  • [1] ANTIBODY RESPONSE AFTER SARS-CoV-2 mRNA VACCINE IN NAIVE AND PREVIOUSLY INFECTED HEALTHCARE WORKERS
    Hutanu, Adina
    Dobreanu, Minodora
    HEALTH PROBLEMS OF CIVILIZATION, 2022, 16 (01) : 48 - 56
  • [2] Vaccine against SARS-CoV-2 in previously infected health care workers
    Parisi, Saverio Giuseppe
    EBIOMEDICINE, 2021, 71
  • [3] Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2
    Havervall, Sebastian
    Marking, Ulrika
    Greilert-Norin, Nina
    Ng, Henry
    Gordon, Max
    Salomonsson, Ann-Christin
    Hellstrom, Cecilia
    Pin, Elisa
    Blom, Kim
    Mangsbo, Sara
    Phillipson, Mia
    Klingstrom, Jonas
    Hober, Sophia
    Nilsson, Peter
    Aberg, Mikael
    Thalin, Charlotte
    EBIOMEDICINE, 2021, 70
  • [4] IgG antibodies against SARS-CoV-2 decay but persist 4 months after vaccination in a cohort of healthcare workers
    Brisotto, Giulia
    Muraro, Elena
    Montico, Marcella
    Corso, Chiara
    Evangelista, Chiara
    Casarotto, Mariateresa
    Caffau, Cristina
    Vettori, Roberto
    Cozzi, Maria Rita
    Zanussi, Stefania
    Turetta, Matteo
    Ronchese, Federico
    Steffan, Agostino
    CLINICA CHIMICA ACTA, 2021, 523 : 476 - 482
  • [5] IgG level of the third booster dose for mRNA of SARS-CoV-2 vaccines among Iraqi healthcare workers
    Rasheed, Waleed S.
    Sarkees, Alaa Noori
    MEDICINE, 2023, 102 (40) : E35444
  • [6] Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: booster required
    İlker İnanc Balkan
    Harika Oyku Dinc
    Gunay Can
    Rıdvan Karaali
    Dogukan Ozbey
    Bilge Caglar
    Ayşe Nur Beytur
    Elif Keskin
    Beyhan Budak
    Okan Aydogan
    Bilgül Mete
    Sevgi Ergin
    Bekir Kocazeybek
    Nese Saltoglu
    Irish Journal of Medical Science (1971 -), 2023, 192 : 19 - 25
  • [7] Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: booster required
    Balkan, Ilker Inanc
    Dinc, Harika Oyku
    Can, Gunay
    Karaali, Ridvan
    Ozbey, Dogukan
    Caglar, Bilge
    Beytur, Ayse Nur
    Keskin, Elif
    Budak, Beyhan
    Aydogan, Okan
    Mete, Bilgul
    Ergin, Sevgi
    Kocazeybek, Bekir
    Saltoglu, Nese
    IRISH JOURNAL OF MEDICAL SCIENCE, 2023, 192 (01) : 19 - 25
  • [8] Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2
    Saadat, Saman
    Tehrani, Zahra Rikhtegaran
    Logue, James
    Newman, Michelle
    Frieman, Matthew B.
    Harris, Anthony D.
    Sajadi, Mohammad M.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (14): : 1467 - 1469
  • [9] Long-term immunogenicity in previously vaccinated healthcare workers with inactivated virus vaccine after SARS-CoV-2 infection or booster vaccination
    Terbsiri, Varalee
    Putcharoen, Opass
    Suwanpimolkul, Gompol
    Jantarabenjakul, Watsamon
    Wacharapluesadee, Supaporn
    Champa, Nuntana
    Thippamom, Nattakarn
    Paitoonpong, Leilani
    VACCINE: X, 2023, 14
  • [10] Immune Response to Single-Dose Moderna Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2
    Moreira-Pinto, Joao
    Gregorio, Susana
    Camarinha, Joao
    Soares, Bruno
    Cunha Ramos, Joao
    ACTA MEDICA PORTUGUESA, 2021, 34 (09): : 630 - 631