Hepatitis B virus genotypes influence clinical outcomes: A review

被引：7
|
作者：
da Silva, Carolina Fernandes [1 ]
Keeshan, Alexa [1 ,2 ]
Cooper, Curtis [1 ,2 ,3 ]
机构：
[1] Ottawa Hosp, Res Inst, Ottawa, ON, Canada
[2] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada
[3] Ottawa Hosp, Gen Campus,G12-501 Smyth Rd, Ottawa, ON K1H 8L6, Canada
来源：
CANADIAN LIVER JOURNAL | 2023年 / 6卷 / 03期
关键词：
cirrhosis; genotype; hepatitis B virus (HBV); hepatocellular carcinoma (HCC); interferon alpha (IFN-& alpha; liver fibrosis; nucleosides; HEPATOCELLULAR-CARCINOMA; HBV GENOTYPES; A1762T/G1764A MUTATIONS; INFECTION; INTERFERON; RISK; VACCINATION; RESISTANCE; CHILDREN; EFFICACY;
D O I：
10.3138/canlivj-2023-0003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis B virus (HBV) is a hepatotropic virus that affects approximately 296 million people worldwide. A crucial step to HBV replication is the transcription of its infectious DNA from its viral RNA intermediate. The production of the RNA intermediate hinges on reverse transcription, and therefore the lack of proofreading in that process commonly yields mutants and has led to nine well-described genotypes (A-I) and over 30 known sub-genotypes of the virus. The influence of genotype on HBV infection outcomes, which include fibrosis progression, cirrhosis, and hepatocellular carcinoma (HCC), remain uncertain. This review aims to analyze the influence of HBV genotype on the risk of development of these outcomes. The response to current and future HBV therapies is considered. Further study of larger and more diverse samples will hopefully resolve outstanding uncertainties.
引用
收藏
页码：347 / 352
页数：6
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