Isovanillic acid protects mice against Staphylococcus aureus by targeting vWbp and Coa

被引：3

作者：

Chen, Xiangqian ^{[1
]}

Hu, Chunjie ^{[1
,2
]}

Shu, Zunhua ^{[1
,3
]}

Wang, Xingye ^{[1
]}

Zhao, Yicheng ^{[1
,4
]}

Song, Wu ^{[1
]}

Chen, Xiaoyu ^{[1
]}

Jin, Mengli ^{[1
]}

Xiu, Yang ^{[1
]}

Guo, Xuerui ^{[5
]}

Kong, Xiangri ^{[1
]}

Jiang, Yijing ^{[1
]}

Guan, Jiyu ^{[6
]}

Gongga, Lanzi ^{[7
]}

Wang, Li ^{[1
]}

Wang, Bingmei ^{[1
]}

机构：

[1] Changchun Univ Chinese Med, Changchun 130117, Peoples R China

[2] Changchun Univ Chinese Med, Affiliated Hosp, Proctol Dept, Changchun 130021, Peoples R China

[3] Changchun Univ Chinese Med, Affiliated Hosp 3, Changchun 130118, Peoples R China

[4] First Hosp Jilin Univ, Ctr Pathogen Biol & Infect Dis, Minist Educ, Key Lab Organ Regenerat & Transplantat, Changchun 130021, Peoples R China

[5] Jilin Univ, Sch Pharm, Changchun 130021, Peoples R China

[6] Jilin Univ, Coll Vet Med, Minist Educ, Key Lab Zoonosis, Changchun 130062, Peoples R China

[7] Tibet Univ Med Coll, Tibet 850000, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2023年 / 18卷 / 11期

基金：

中国国家自然科学基金;

关键词：

coagulase; isovanillic acid; pneumonia; Staphylococcus aureus; von Willebrand factor binding protein; FACTOR-BINDING PROTEIN; ENDOCARDITIS; COAGULASE; ADHESION; ANTIBACTERIAL; AGGREGATION; PNEUMONIA; VIRULENCE; DEFENSE;

D O I：

10.2217/fmb-2022-0219

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: Our primary objective was to investigate the protective effects and mechanisms of isovanillic acid in mice infected with Staphylococcus aureus Newman. Methods: In vitro coagulation assays were used to validate vWbp and Coa as inhibitory targets of isovanillic acid. The binding mechanism of isovanillic acid to vWbp and Coa was investigated using molecular docking and point mutagenesis. Importantly, a lethal pneumonia mouse model was used to assess the effect of isovanillic acid on survival and pathological injury in mice. Results & Conclusion: Isovanillic acid reduced the virulence of S. aureus by directly binding to inhibit the clotting activity of vWbp and Coa, thereby reducing lung histopathological damage and improving the survival rate in mice with pneumonia.

引用

页码：735 / 749

页数：15

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