The role of sialidase Neu1 in respiratory diseases

被引：3
|
作者：
Mei, Shiran [1 ]
Li, Dingding [1 ]
Wang, Aoyi [1 ]
Zhu, Guoxue [1 ]
Zhou, Bingwen [1 ]
Li, Nian [1 ]
Qin, Yi [1 ]
Zhang, Yanliang [1 ,2 ]
Jiang, Shujun [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Nanjing, Peoples R China
[2] Nanjing Res Ctr Infect Dis Integrated Tradit Chine, Nanjing, Jiangsu, Peoples R China
来源：
RESPIRATORY RESEARCH | 2024年 / 25卷 / 01期
关键词：
IDIOPATHIC PULMONARY-FIBROSIS; SELECTIVE INHIBITORS; HUMAN NEURAMINIDASE; LYSOSOMAL SIALIDASE; T-LYMPHOCYTES; LUNG-CANCER; EXPRESSION; RECEPTOR; CD44; DIFFERENTIATION;
D O I：
10.1186/s12931-024-02763-9
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a variety of cellular processes, including cellular signaling and inflammation. In recent years, numerous evidence has suggested that human NEU1 is also involved in the pathogenesis of various respiratory diseases, including lung infection, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. This review paper aims to provide an overview of the current research on human NEU1 and respiratory diseases.
引用
收藏
页数：8
相关论文
共 50 条
  • [31] Pathogen Molecule-Induced Toll-Like Receptor Activation and Cell Function is Dependent on Neu1 Sialidase
    Amith, Schammim Ray
    Jayanth, Preethi
    Franchuk, Susan
    Siddiqui, Sarah
    Seyrantepe, Volkan
    Gee, Katrina
    Basta, Sam
    Beyaert, Rudi
    Pshezhetsky, Alexey
    Szewczuk, Myron
    GLYCOBIOLOGY, 2009, 19 (11) : 1290 - 1290
  • [32] Neu1 sialidase interacts with perilipin 1 on lipid droplets and inhibits lipolysis in 3T3-L1 adipocytes
    Natori, Yujin
    Nasui, Miwako
    Kihara-Negishi, Fumiko
    GENES TO CELLS, 2017, 22 (05) : 485 - 492
  • [33] Progress of Neu1 and Related Signaling Pathway
    Liu Chang-Mei
    Li Xiang
    Guan Feng
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2016, 43 (10) : 962 - 969
  • [34] Selective Inhibitors of Human Neuraminidase 1 (NEU1)
    Guo, Tianlin
    Heon-Roberts, Rachel
    Zou, Chunxia
    Zheng, Ruixiang
    Pshezhetsky, Alexey V.
    Cairo, Christopher W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (24) : 11261 - 11279
  • [35] Molecular pathology of NEU1 gene in sialidosis
    Seyrantepe, V
    Poulpetova, H
    Froissart, R
    Zabot, MT
    Marie, I
    Pshezhetsky, AV
    HUMAN MUTATION, 2003, 22 (05) : 343 - 352
  • [36] NEU1 is a negative regulator of lysosomal exocytosis
    d'Azzo, Alessandra
    Bonten, Erik
    Van de Vlekkert, Diantha
    Yogalingam, Gouri
    MOLECULAR GENETICS AND METABOLISM, 2009, 96 (02) : S20 - S20
  • [37] Modulation of TLR4 Sialylation Mediated by a Sialidase Neu1 and Impairment of Its Signaling in Leishmania donovani Infected Macrophages
    Karmakar, Joyshree
    Roy, Saptarshi
    Mandal, Chitra
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [38] Overexpression of MyoD-inducible lysosomal sialidase (neu1) inhibits myogenesis in C2C12 cells
    Champigny, MJ
    Perry, R
    Rudnicki, M
    Igdoura, SA
    EXPERIMENTAL CELL RESEARCH, 2005, 311 (01) : 157 - 166
  • [39] A point mutation in the neu1 promoter recruits an ectopic repressor, NkX3.2 and results in a mouse model of sialidase deficiency
    Champigny, Marc J.
    Mitchell, Mark
    Fox-Robichaud, Alison
    Trigatti, Bernardo L.
    Igdoura, Suleiman A.
    MOLECULAR GENETICS AND METABOLISM, 2009, 97 (01) : 43 - 52
  • [40] NEU1 Sialidase Expressed in Human Airway Epithelia Regulates Epidermal Growth Factor Receptor (EGFR) and MUC1 Protein Signaling
    Lillehoj, Erik P.
    Hyun, Sang Won
    Feng, Chiguang
    Zhang, Lei
    Liu, Anguo
    Guang, Wei
    Nguyen, Chinh
    Luzina, Irina G.
    Atamas, Sergei P.
    Passaniti, Antonino
    Twaddell, William S.
    Puche, Adam C.
    Wang, Lai-Xi
    Cross, Alan S.
    Goldblum, Simeon E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (11) : 8214 - 8231
12345