Mass spectrometry-based proteomic applications in dental implants research

被引：1
|
作者：
Halstenbach, Tim [1 ]
Topitsch, Annika [1 ,2 ,3 ,4 ]
Schilling, Oliver [2 ]
Iglhaut, Gerhard [1 ]
Nelson, Katja [1 ]
Fretwurst, Tobias [1 ,5 ]
机构：
[1] Univ Freiburg, Fac Med, Med Ctr, Dept Oral and Craniomaxillofacial Surg Translat Im, Freiburg, Germany
[2] Univ Freiburg, Inst Surg Pathol, Fac Med, Med Ctr, Freiburg, Germany
[3] Univ Freiburg, Spemann Grad Sch Biol & Med SGBM, Freiburg, Germany
[4] Univ Freiburg, Fac Biol, Freiburg, Germany
[5] Univ Freiburg, Fac Med, Med Ctr, Dept Oral and Craniomaxillofacial Surg Translat Im, Hugstetter Str 55, D-79106 Freiburg, Germany
来源：
PROTEOMICS CLINICAL APPLICATIONS | 2024年 / 18卷 / 03期
关键词：
alveolar bone; dental implants; peri-implant crevicular fluid; peri-implantitis; proteomics; BONE LOSS BIOMARKERS; PERI-IMPLANTITIS; CREVICULAR FLUID; MATRIX METALLOPROTEINASE-8; NATURAL TEETH; GINGIVAL; HEALTH; PERIODONTITIS; EXPRESSION; DISEASE;
D O I：
10.1002/prca.202300019
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Dental implants have been established as successful treatment options for missing teeth with steadily increasing demands. Today, the primary areas of research in dental implantology revolve around osseointegration, soft and hard tissue grafting as well as peri-implantitis diagnostics, prevention, and treatment. This review provides a comprehensive overview of the current literature on the application of MS-based proteomics in dental implant research, highlights how explorative proteomics provided insights into the biology of peri-implant soft and hard tissues and how proteomics facilitated the stratification between healthy and diseased implants, enabling the identification of potential new diagnostic markers. Additionally, this review illuminates technical aspects, and provides recommendations for future study designs based on the current evidence.
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收藏
页数：16
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