A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities

被引：29

作者：

Nardi, Monica ^{[1
]}

Cano, Natividad Carolina Herrera ^{[2
]}

Simeonov, Svilen ^{[3
,4
]}

Bence, Renata ^{[2
]}

Kurutos, Atanas ^{[3
]}

Scarpelli, Rosa ^{[1
]}

Wunderlin, Daniel ^{[2
]}

Procopio, Antonio ^{[1
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Viale Europa, I-88100 Catanzaro, Italy

[2] Univ Nacl Cordoba, Fac Ciencias Quim, ICYTAC CONICET, Dept Quim Organ, Ciudad Univ, RA-5000 Cordoba, Argentina

[3] Bulgarian Acad Sci, Inst Organ Chem Ctr Phytochemistry, Acad G Bonchev str, bl 9, Sofia 1113, Bulgaria

[4] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal

来源：

CATALYSTS | 2023年 / 13卷 / 02期

关键词：

benzimidazole; green chemistry; pharmacological activity; DNA MINOR-GROOVE; MICROWAVE-ASSISTED SYNTHESIS; II RECEPTOR ANTAGONISTS; ANGIOTENSIN-II; BIOLOGICAL EVALUATION; CRYSTAL-STRUCTURE; EFFICIENT SYNTHESIS; SOLVENT-FREE; 2-SUBSTITUTED BENZIMIDAZOLES; ORAL ANTICOAGULANTS;

D O I：

10.3390/catal13020392

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic chemistry. The use of non-environmental organic compounds and application high energy synthetic methods, the production of waste, and the application of conventional toxic processes are a problem for the pharmaceutical industry and for these important drugs' synthesis. The substituted benzimidazoles are summarized in this review to provide insight about their organic synthesis using ecofriendly methods, as well as their pharmacological activities.

引用

页数：35

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