Future directions for medicinal chemistry in the field of oligonucleotide therapeutics

被引：9

作者：

Hall, Jonathan ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

RNA | 2023年 / 29卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

ANTISENSE OLIGONUCLEOTIDES; TARGETED DELIVERY; STEREOCONTROLLED SYNTHESIS; LIPID NANOPARTICLES; APOLIPOPROTEIN-B; GENE; RNA; INHIBITION; RECEPTOR; POTENCY;

D O I：

10.1261/rna.079511.122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the last decade, the field of oligonucleotide therapeutics has matured, with the regulatory approval of several single-stranded and double-stranded RNA drugs. In this Perspective, I discuss enabling developments and likely future directions in the field from the perspective of oligonucleotide chemistry.

引用

页码：423 / 433

页数：11

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