Future directions for medicinal chemistry in the field of oligonucleotide therapeutics

被引：6

作者：

Hall, Jonathan ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

RNA | 2023年 / 29卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

ANTISENSE OLIGONUCLEOTIDES; TARGETED DELIVERY; STEREOCONTROLLED SYNTHESIS; LIPID NANOPARTICLES; APOLIPOPROTEIN-B; GENE; RNA; INHIBITION; RECEPTOR; POTENCY;

D O I：

10.1261/rna.079511.122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the last decade, the field of oligonucleotide therapeutics has matured, with the regulatory approval of several single-stranded and double-stranded RNA drugs. In this Perspective, I discuss enabling developments and likely future directions in the field from the perspective of oligonucleotide chemistry.

引用

页码：423 / 433

页数：11

共 50 条

[1] Medicinal Chemistry of Oligonucleotide Drugs Milestones of the Past and Visions for the Future
Hall, Jonathan
Ashkinadze, Anastasia
Becker, Jan Philipp
Laski, Artur
Manz, Eva-Maria
Moravcik, Stefan
Sjoestroem, Sebastian
Vincent, Mathilde
[J]. CHIMIA, 2022, 76 (05) : 466 - 473
[2] Sustainable Practices in Medicinal Chemistry: Current State and Future Directions
Bryan, Marian C.
Dillon, Barry
Hamann, Lawrence G.
Hughes, Gregory J.
Kopach, Michael E.
Peterson, Emily A.
Pourashraf, Mehrnaz
Raheem, Izzat
Richardson, Paul
Richter, Daniel
Sneddon, Helen F.
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (15) : 6007 - 6021
[3] Medicinal chemistry of combretastatin A4: Present and future directions
Tron, GC
Pirali, T
Sorba, G
Pagliai, F
Busacca, S
Genazzani, AA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (11) : 3033 - 3044
[4] Computational approaches in medicinal chemistry: Surveys, case studies and future directions
Lushington, GH
[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2006, 6 (01) : 1 - 1
[5] Future Directions in Osteoporosis Therapeutics
Bone, Henry
[J]. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2012, 41 (03) : 655 - +
[6] INDOLES AS THERAPEUTICS OF INTEREST IN MEDICINAL CHEMISTRY
Buvana, C.
Suresh, R.
Haribabu, Y.
Manna, P. K.
[J]. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (03): : 1585 - 1602
[7] Oligonucleotide therapeutics: chemistry, delivery and clinical progress
Sharma, Vivek K.
Watts, Jonathan K.
[J]. FUTURE MEDICINAL CHEMISTRY, 2015, 7 (16) : 2221 - 2242
[8] Chemistry, structure and function of approved oligonucleotide therapeutics
Egli, Martin
Manoharan, Muthiah
[J]. NUCLEIC ACIDS RESEARCH, 2023, 51 (06) : 2529 - 2573
[9] New Momentum for the Field of Oligonucleotide Therapeutics
Aartsma-Rus, Annemieke
[J]. MOLECULAR THERAPY, 2016, 24 (02) : 193 - 194
[10] Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions
Chiang, Linus
Jones, Michael R.
Ferreira, Cara L.
Storr, Tim
[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2012, 12 (03) : 122 - 144

← 1 2 3 4 5 →