Overlapping Epstein-Barr virus encephalitis and autoimmune glial fibrillary acidic protein astrocytopathy

被引：4

作者：

Zhang, Jin-ru ^{[1
,2
]}

Zhuang, Sheng ^{[1
,2
]}

Xu, Xiao-dong ^{[1
,2
]}

Song, Wen-li ^{[1
,2
]}

Li, Ke-ru ^{[1
,2
]}

Jiang, Yu ^{[1
,2
]}

Cheng, Xiao-yu ^{[1
,2
]}

Shi, Ji-jun ^{[1
,2
]}

Hu, Wei-dong ^{[1
,2
,5
]}

Liu, Chun-feng ^{[1
,2
,3
,4
,5
]}

Zhang, Yan-lin ^{[1
,2
,5
]}

机构：

[1] Soochow Univ, Dept Neurol, Affiliated Hosp 2, Suzhou, Peoples R China

[2] Soochow Univ, Suzhou Clin Res Ctr Neurol Dis, Affiliated Hosp 2, Suzhou, Peoples R China

[3] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Peoples R China

[4] Soochow Univ, Inst Neurosci, Suzhou, Peoples R China

[5] Soochow Univ, Dept Neurol, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215004, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 382卷

关键词：

Autoimmune glial fibrillary acidic protein astrocytopathy; Epstein-Barr virus encephalitis; Acute disseminated encephalomyelitis;

D O I：

10.1016/j.jneuroim.2023.578174

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe three cases of overlapping Epstein-Barr virus (EBV) Encephalitis and Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy (GFAP-A). The three cases all presented with initial symptoms of fever, headache, coma, and posture tremor of the upper limbs, then followed by limb weakness and dysuria. All of the three cases were on ventilators. Case 1 and 2 improved dramatically after intravenous methylprednisoloneand immuno-globulin treatment. However, case 3 presented dyspneic, and died from gastrointestinal hemorrhage. The GFAP-A triggered by EBV intracranial infection could initially masquerade as EBV encephalitis only, and the detection of GFAP antibody is essential for differentiation.

引用

页数：5

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