Rehabilitation services are among the most severely impacted by the COVID-19 pandemic. This has increased the number of people not receiving the needed rehabilitation care. Home-based rehabilitation becomes alternative support to face this greater need. However, monitoring kinematics parameters during rehabilitation exercises is critical for an effective recovery. This work proposes a detailed framework to estimate knee kinematics using a wearable Magnetic and Inertial Measurement Unit (MIMU). That allows at-home monitor -ing for knee rehabilitation progress. Two MIMU sensors were attached to the shank and thigh segments respectively. First, the absolute orientation of each sensor was estimated using a sensor fusion algorithm. Second, these sensor orientations were transformed to segments orientations using a functional sensor-to-segment (STS) alignment. Third, the rel-ative orientation between segments, i.e., knee joint angle, was computed and the relevant kinematics parameters were extracted. Then, the validity of our approach was evaluated with a gold-standard optoelectronic system. Seven participants completed three to five Timed-Up-and-Go (TUG) tests. The estimated knee angle was compared to the reference angle. Root-mean-square error (RMSE), correlation coefficient, and Bland-Altman analysis were considered as evaluation metrics. Our results showed reasonable accuracy (RMSE < 8 degrees), strong to very-strong correlation (correlation coefficient > 0.86), a mean difference within 1.1 degrees, and agreement limits from-16 degrees to 14 degrees. In addition, no significant difference was found ( p-value > 0.05) in extracted kinematics parameters between both systems. The proposed approach might represent a suitable alternative for the assessment of knee reha-bilitation progress in a home context.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )