Dysambiol, an Anti-inflammatory Secomeroterpenoid from a Dysidea sp. Marine Sponge

被引：0

作者：

Jiao, Wei-Hua ^{[1
]}

Li, Jia-Xin ^{[1
]}

Liu, Hong-Yan ^{[1
,2
]}

Luo, Xiang-Chao ^{[1
]}

Hu, Tian-Yong ^{[3
,4
]}

Shi, Guo-Hua ^{[1
]}

Xie, Dong-Dong ^{[1
]}

Chen, Hai-Feng ^{[2
]}

Cheng, Bao-Hui ^{[3
,4
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Ren Ji Hosp, Res Ctr Marine Drugs, Sch Med,State Key Lab Microbial Metabolism,Dept Ph, Shanghai 200127, Peoples R China

[2] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361102, Peoples R China

[3] Longgang ENT Hosp, Dept Otolaryngol, Shenzhen 518172, Peoples R China

[4] Inst ENT, Shenzhen Key Lab ENT, Shenzhen 518172, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 34期

基金：

中国国家自然科学基金;

关键词：

SESQUITERPENE-QUINONES; A-C; MEROTERPENOIDS; MACROLIDE;

D O I：

10.1021/acs.orglett.3c02409

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with a rare lactone bridge. The structure of 1 was determined by extensive spectroscopic analysis, Mosher's method, and electronic circular dichroism calculation. Dysambiol displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-?B/MPAK signaling pathway.

引用

页码：6391 / 6395

页数：5

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