Bioactive Polybrominated diphenyl ethers from the marine sponge Dysidea sp.

被引：30
|
作者：
Zhang, Hui [1 ]
Skildum, Andrew [3 ]
Stromquist, Emily [1 ]
Rose-Hellekant, Teresa [3 ]
Chang, Leng Chee [1 ,2 ]
机构：
[1] Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55812 USA
[2] Univ Hawaii, Coll Pharm, Hilo, HI 96720 USA
[3] Univ Minnesota, Sch Med, Dept Physiol & Pharmacol, Duluth, MN 55812 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 02期
关键词：
D O I：
10.1021/np070244y
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new polybrominated diphenyl ether (9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.
引用
收藏
页码：262 / 264
页数：3
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