Partially Reversible Immunodeficiency After In-Utero Exposure to Immunosuppressants

被引：0

作者：

Goessling, Katharina L. ^{[1
]}

Kobbe, Robin ^{[2
,3
,4
]}

Boetticher, Benedikt ^{[1
]}

Soura, Stavrieta ^{[1
]}

Borkhardt, Arndt ^{[1
]}

Wittkowski, Helmut ^{[5
]}

Schwab, Matthias ^{[6
,7
]}

Kobbe, Guido ^{[8
]}

Neubert, Jennifer ^{[1
]}

Ghosh, Sujal ^{[1
]}

Laws, Hans-Juergen ^{[1
]}

Oommen, Prasad Thomas ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Inst Infect Res & Vaccine Dev IIRVD, Hamburg, Germany

[3] Bernhard Nocht Inst Trop Med, Dept Infect Dis Epidemiol, Hamburg, Germany

[4] Bernhard Nocht Inst Trop Med BNITM, Dept Infect Epidemiol, Hamburg, Germany

[5] Univ Childrens Hosp Munster, Dept Pediat Rheumatol & Immunol, Munster, Germany

[6] Dr Margarete F Bosch Inst Clin Pharmacol, Stuttgart, Germany

[7] Univ Hosp Tubingen, Inst Expt & Clin Pharmacol & Toxicol, Tubingen, Germany

[8] Univ Hosp Dusseldorf, Dept Haematol Oncol & Clin Immunol, Dusseldorf, Germany

来源：

DEUTSCHES ARZTEBLATT INTERNATIONAL | 2023年 / 120卷 / 46期

关键词：

D O I：

10.3238/arztebl.m2023.0200

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment with immunosuppressants affects pregnant women too. The European League Against Rheumatism (EULAR) has published recommendations for action for the use of immuno - suppressants in pregnancy; azathioprine (n=72) and rituximab (n=256) were not associated with increased rates of miscarriage or malformations (1). But long term data on the effects on children's immune reconstitution after exposure to these substances are lacking (2). We report on three cases of exposure to rituximab or azathioprine in utero that led to partly reversible, partly sustained immunodeficiency. © 2023 Deutscher Arzte-Verlag GmbH. All rights reserved.

引用

页码：795 / 796

页数：2

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