Two new monoterpenoid indole alkaloids from the kernels of Kopsia arborea

被引：2

作者：

Chen, Chen ^{[1
,2
]}

Ding, Xiao ^{[2
]}

Han, Lingling ^{[2
]}

Zhu, Wentao ^{[2
]}

Huang, Kepu ^{[2
]}

Hao, Xiaojiang ^{[2
]}

Zhang, Yu ^{[2
]}

机构：

[1] Yunnan Univ, Sch Life Sci, Kunming, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 07期

基金：

美国国家科学基金会;

关键词：

Apocynaceae; Kopsia arborea; kernels; monoterpene indole alkaloids; OFFICINALIS;

D O I：

10.1080/14786419.2021.1984911

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new monoterpenoid indole alkaloids, (2 R, 7 R, 16 R, 20 R, 21S)-12-hydroxypleiocarpine (1) and (2S, 7 R, 16S, 20 R, 21S)-N-methoxycarbonyl-11,12-methylenedioxy-Delta(14,15)-kopsinaline (2), along with six known alkaloids were isolated from the methanol extract of the kernels of Kopsia arborea. Their structures including the absolute configurations were elucidated by HRESIMS, NMR spectroscopy, and quantum computational methods. Their cytotoxicity against two human cancer cell lines were also evaluated.

引用

页码：1047 / 1052

页数：6

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