Increased intracellular miR-142 in adults with Type 1 diabetes

被引：0
|
作者：
Huang, Li [1 ,2 ]
Januszewski, Andrzej S. [3 ,4 ,5 ]
Takahashi, Yusuke [1 ,6 ]
O'Neal, David N. [3 ,4 ,7 ]
Ma, Jian-Xing [1 ,6 ,8 ]
Jenkins, Alicia J. [3 ,4 ,7 ,8 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK USA
[2] Fujian Med Univ Union Hosp, Dept Ophthalmol, Fuzhou, Fujian, Peoples R China
[3] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW, Australia
[4] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
[5] Univ Sydney, Sydney Pharm Sch, Sydney, NSW, Australia
[6] Wake Forest Univ, Sch Med, Dept Biochem, Med Ctr Blvd, Winston Salem, NC 27157 USA
[7] St Vincents Hosp, Dept Endocrinol & Diabet, Melbourne, Vic, Australia
[8] Baker Heart & Diabet Inst, 75 Commercial Rd, Melbourne, Vic 3004, Australia
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2023年 / 37卷 / 10期
关键词：
Type; 1; diabetes; miR-142; microvascular complications; TERM FENOFIBRATE THERAPY; MELLITUS; PEOPLE; CELL;
D O I：
10.1016/j.jdiacomp.2023.108597
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
microRNAs (miRs), including miR-142, modulate gene expression and processes implicated in vascular damage and may serve as therapeutic targets and agents, including in Type 1 diabetes (T1D). The project aimed to assess whether miR-142 levels differ between people with and without T1D, and to analyse miR-142 associations with cardiovascular (CVD) risk factors. Intracellular miRs were isolated from whole blood cell pellets using TRIzol-based methodology. In a cross-sectional study in 102 adults cellular miR-142 levels were significantly higher (on unadjusted and adjusted analyses) in 69 adults with T1D relative to 33 non-diabetic subjects: mean +/- SD, 3.53 +/- 3.66 vs. 1.25 +/- 0.78, p < 0.0002, but were not related to HbA1c levels. Further miR-142 research, including longitudinal and intervention studies and basic science are of interest. miR-142 may be valuable in clinical practice for predicting health and as a treatment target.
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页数：3
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