Fabrication of targeted gold nanoparticle as potential contrast agent in molecular CT imaging

被引：10
|
作者：
Malekzadeh, Reza [1 ,2 ]
Ghorbani, Marjan [3 ]
Faghani, Parsa [4 ]
Abdollahi, Behnaz Babaye [1 ]
Mortezazadeh, Tohid [1 ]
Farhood, Bagher [5 ]
机构：
[1] Tabriz Univ Med Sci, Sch Med, Dept Med Phys, Tabriz, Iran
[2] Tabriz Univ Med Sci, Med Radiat Sci Res Team, Tabriz, Iran
[3] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[4] Shiraz Univ Med Sci, Sch Med, Dept Med Phys, Shiraz, Iran
[5] Kashan Univ Med Sci, Fac Paramed Sci, Dept Med Phys & Radiol, Kashan, Iran
来源：
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES | 2023年 / 16卷 / 01期
关键词：
Contrast agent; Molecular CT imaging; Trastuzumab; Gold nanoparticles; Cancer; BIODISTRIBUTION; IODINE; MRI;
D O I：
10.1016/j.jrras.2022.100490
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Trastuzumab (TZ) multifunctional Fe3O4 coated gold nanoparticles (Au NPs) through polyethylene glycol (PEG) linking for targeted molecular computed tomography (CT) imaging was developed. The prepared TZ-PEG-Fe3O4@Au NPs were fully characterized and cytocompatibility, X-ray attenuation measurement, and in vitro cell targeting ability were analyzed. The findings showed that the synthesized NPs, with a size of less than 100 nm, were non-toxic at specific concentration ranges, and exhibit better X-ray attenuation intensity than iodine-based contrast agents at the same concentration. The created targeted NPs can be employed as a contrast agent for molecular targeted CT imaging of cancer cells expressing the human epidermal growth factor receptor 2 (HER-2).
引用
收藏
页数：9
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