The role of Hippo pathway in ferroptosis

被引：13
|
作者：
Xiang, Jiangxia [1 ]
Jiang, Mengmeng [2 ]
Du, Xing [3 ,4 ]
机构：
[1] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Traumatol, Chongqing, Peoples R China
[2] Third Cent Hosp Tianjin, Dept Med Oncol, Tianjin, Peoples R China
[3] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China
[4] Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 12卷
关键词：
Hippo pathway; YAP; ferroptosis; iron metabolism; ROS; TUMOR-SUPPRESSOR; LIPID-PEROXIDATION; HUMAN HEALTH; CELL-DEATH; KINASES; CANCER; TEAD; PHOSPHORYLATION; IDENTIFICATION; MERLIN/NF2;
D O I：
10.3389/fonc.2022.1107505
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of Hippo pathway in ferroptosisThe Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors.
引用
收藏
页数：8
相关论文
共 50 条
  • [31] The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease
    Zhuo Xie
    Ying Wang
    Guang Yang
    Jing Han
    Liguo Zhu
    Li Li
    Shenghong Zhang
    Cell Death & Disease, 12
  • [32] Role of Hippo signaling pathway in early placental development
    Soncin, Francesca
    Parast, Mana M.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (34) : 20354 - 20356
  • [33] Emerging role of Hippo signalling pathway in bladder cancer
    Xia, Jianling
    Zeng, Ming
    Zhu, Hua
    Chen, Xiangjian
    Weng, Zhiliang
    Li, Shi
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (01) : 4 - 15
  • [34] Emerging Role of YAP and the Hippo Pathway in Prostate Cancer
    Koinis, Filippos
    Chantzara, Evangelia
    Samarinas, Michael
    Xagara, Anastasia
    Kratiras, Zisis
    Leontopoulou, Vasiliki
    Kotsakis, Athanasios
    BIOMEDICINES, 2022, 10 (11)
  • [35] The Role of Hippo Signaling Pathway in the Development of the Nervous System
    Li, Xifan
    Li, Kaixuan
    Chen, Yu
    Fang, Fang
    DEVELOPMENTAL NEUROSCIENCE, 2021, 43 (05) : 263 - 270
  • [36] The role of Hippo signal pathway in breast cancer metastasis
    Wei, Changran
    Wang, Ying
    Li, Xiangqi
    ONCOTARGETS AND THERAPY, 2018, 11 : 2185 - 2193
  • [37] The critical role of the Hippo signaling pathway in kidney diseases
    Sun, Yuting
    Jin, De
    Zhang, Ziwei
    Jin, Di
    Xue, JiaoJiao
    Duan, LiYun
    Zhang, YuQing
    Kang, XiaoMin
    Lian, FengMei
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [38] The role of Hippo signaling pathway in physiological cardiac hypertrophy
    Gholipour, Majid
    Tabrizi, Arezoo
    BIOIMPACTS, 2020, 10 (04) : 250 - 256
  • [39] The Role of Hippo Pathway in Cancer Stem Cell Biology
    Park, Jae Hyung
    Shin, Ji Eun
    Park, Hyun Woo
    MOLECULES AND CELLS, 2018, 41 (02) : 83 - 92
  • [40] The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease
    Xie, Zhuo
    Wang, Ying
    Yang, Guang
    Han, Jing
    Zhu, Liguo
    Li, Li
    Zhang, Shenghong
    CELL DEATH & DISEASE, 2021, 12 (01)
12345