The role of Hippo pathway in ferroptosis

被引：13
|
作者：
Xiang, Jiangxia [1 ]
Jiang, Mengmeng [2 ]
Du, Xing [3 ,4 ]
机构：
[1] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Traumatol, Chongqing, Peoples R China
[2] Third Cent Hosp Tianjin, Dept Med Oncol, Tianjin, Peoples R China
[3] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China
[4] Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 12卷
关键词：
Hippo pathway; YAP; ferroptosis; iron metabolism; ROS; TUMOR-SUPPRESSOR; LIPID-PEROXIDATION; HUMAN HEALTH; CELL-DEATH; KINASES; CANCER; TEAD; PHOSPHORYLATION; IDENTIFICATION; MERLIN/NF2;
D O I：
10.3389/fonc.2022.1107505
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of Hippo pathway in ferroptosisThe Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors.
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页数：8
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