Solvent-switchable regioselective 1,2-or 1,6-addition of quinones with boronic acids

被引：2
|
作者：
Xia, Qi [1 ]
Zhou, Yaxuan [1 ]
Yang, Xiaoning [1 ]
Zhang, Yanqiu [1 ]
Wang, Jiayi [1 ]
Song, Gonghua [1 ]
机构：
[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 54期
关键词：
C-H ARYLATION; BIOSYNTHESIS;
D O I：
10.1039/d3cc01968c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient copper-catalyzed solvent-switchable regioselective 1,2- or 1,6-addition of quinones with boronic acids has been developed. This novel catalytic protocol for the synthesis of various quinols and 4-phenoxyphenols was enabled by a simple solvent swap between H2O and MeOH. It features mild reaction conditions, simple and easy operation, broad substrate scope and excellent regioselectivity. The gram-scale reactions as well as the further transformations of both addition products were also successfully investigated.
引用
收藏
页码：8416 / 8419
页数：4
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