Solvent-switchable regioselective 1,2-or 1,6-addition of quinones with boronic acids

被引：2

作者：

Xia, Qi ^{[1
]}

Zhou, Yaxuan ^{[1
]}

Yang, Xiaoning ^{[1
]}

Zhang, Yanqiu ^{[1
]}

Wang, Jiayi ^{[1
]}

Song, Gonghua ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 54期

关键词：

C-H ARYLATION; BIOSYNTHESIS;

D O I：

10.1039/d3cc01968c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient copper-catalyzed solvent-switchable regioselective 1,2- or 1,6-addition of quinones with boronic acids has been developed. This novel catalytic protocol for the synthesis of various quinols and 4-phenoxyphenols was enabled by a simple solvent swap between H2O and MeOH. It features mild reaction conditions, simple and easy operation, broad substrate scope and excellent regioselectivity. The gram-scale reactions as well as the further transformations of both addition products were also successfully investigated.

引用

页码：8416 / 8419

页数：4

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