Pd-Catalyzed Carbonylations of Aryl/Heteroaryl Halides in Aqueous Micellar Media

被引：6

作者：

Caravez, Juan C. ^{[1
]}

Wong, Madison J. ^{[1
]}

Kavthe, Rahul D. ^{[1
]}

Takale, Balaram S. ^{[1
]}

Lipshutz, Bruce H. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ACS CATALYSIS | 2023年 / 13卷 / 18期

关键词：

carbonylation; micellar catalysis; tungstenhexacarbonyl; Pd catalysis; green chemistry; CROSS-COUPLINGS; CARBON-MONOXIDE; AMINOCARBONYLATION; WATER; CO; CO-2(CO)(8); AMINES; SALTS;

D O I：

10.1021/acscatal.3c01757

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Formation of amides, acids, and thioesters are readily fashioned from precursor aryl/heteroaryl halides under micellar catalysis conditions using W(CO)(6) as a source of carbon monoxide. Loadings of ligated palladium catalysts are usually in the 0.5 mol % range. Yields with iodides tended to be higher than those using bromides. Applications to targets in the pharmaceutical industry are demonstrated, as are cases from the Merck Informer Library. Both E Factor calculations and options for recycling the aqueous reaction medium are presented.

引用

页码：12383 / 12390

页数：8

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