Discovery of potential PD-L1 small molecule inhibitors as novel cancer therapeutics using machine learning-based QSAR models: A virtual drug repurposing study

被引：0

作者：

Siyah, Pinar ^{[1
]}

Durdagi, Serdar ^{[2
]}

Aksoydan, Busecan ^{[1
]}

机构：

[1] Bahcesxehir Univ, Sch Pharm, Istanbul, Turkiye

[2] Bahcesxehir Univ, Dept Biophys, Istanbul, Turkiye

来源：

BIOPHYSICAL JOURNAL | 2023年 / 122卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

706-Pos

引用

页码：144A / 144A

页数：1

共 38 条

[1] Novel, small molecule PD-L1 inhibitors for cancer immunotherapy
Sivanandhan, D.
Garapaty, S.
Seerapu, G. P.
Das, R.
Kar, R.
Singh, A. K.
Kumar, V. Ashok
Venkateshappa, C.
Putta, R.
Pendyala, M.
Jadhav, T.
Wani, A. E.
Ghanta, S.
Birudukota, S.
Gogoi, H.
Nadig, H.
Gangaiah, R.
Mohd, Z.
Athisayamani, J.
Rajagopal, S.
[J]. EUROPEAN JOURNAL OF CANCER, 2018, 103 : E79 - E79
[2] Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy
Xu, Yongling
Du, Huijie
Guo, Weibo
Liu, Beibei
Yan, Wenxin
Zhang, Chi
Qin, Long
Huang, Jingling
Wang, Hongxia
Wu, Shiqi
Ren, Weijie
Zou, Yi
Wang, Jie
Zhu, Qihua
Xu, Yungen
Gu, Hongfeng
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (05) : 4083 - 4099
[3] Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy
Yang, Zichao
Liu, Ziqing
Wan, Shanhe
Xu, Jianwei
Huang, Yaqi
He, Haiqi
Liu, Ting
Li, Ling
Ren, Yichang
Zhang, Jiajie
Chen, Jianjun
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (10) : 7995 - 8019
[4] Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation
Wu, Tingting
Cheng, Hu
Sima, Lijie
Wang, Zhongyuan
Ouyang, Weiwei
Wang, Jianta
Hou, Yunlei
Zhao, Dongsheng
Liao, Weike
Hu, Chujiao
[J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2024, 39 (01)
[5] Towards novel small-molecule inhibitors blocking PD-1/PD-L1 pathway: From explainable machine learning models to molecular dynamics simulation
Wu, Xiaoyan
Liang, Jingyi
Meng, Luming
Wang, Bingfeng
Liu, Boping
Jin, Yulong
[J]. International Journal of Biological Macromolecules, 2024, 282
[6] Computational discovery of small drug-like compounds as potential inhibitors of PD-1/PD-L1 interactions
Urban, Viktor A.
Davidovskii, Alexander, I
Veresov, Valery G.
[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (11): : 5345 - 5361
[7] Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy
Zhang, Hongbo
Xia, Yu
Yu, Chunqiu
Du, Huijie
Liu, Jinchang
Li, Hui
Huang, Shihui
Zhu, Qihua
Xu, Yungen
Zou, Yi
[J]. MOLECULES, 2021, 26 (11): : 3347
[8] Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction
Sasmal, Pujan
Babasahib, Sajeev Kumar
Kumar, B. R. Prashantha
Raghavendra, Nulgumnalli Manjunathaiah
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 73
[9] Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy
Shengzhe Jin
Hongfei Wang
Yang Li
Jingwen Yang
Beibei Li
Peishang Shi
Xiangrui Zhang
Xiaowen Zhou
Xiuman Zhou
Xiaoshuang Niu
Menghan Wu
Yahong Wu
Wenjie Zhai
Yuanming Qi
Yanfeng Gao
Wenshan Zhao
[J]. Cell Communication and Signaling, 22
[10] Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy
Jin, Shengzhe
Wang, Hongfei
Li, Yang
Yang, Jingwen
Li, Beibei
Shi, Peishang
Zhang, Xiangrui
Zhou, Xiaowen
Zhou, Xiuman
Niu, Xiaoshuang
Wu, Menghan
Wu, Yahong
Zhai, Wenjie
Qi, Yuanming
Gao, Yanfeng
Zhao, Wenshan
[J]. CELL COMMUNICATION AND SIGNALING, 2024, 22 (01)

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