Naturally Occurring Asterric Acid Analogs: Chemistry and Biology

被引：0

作者：

Tan, Yue ^{[1
]}

Chen, Lin ^{[2
]}

Ding, Gang ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, State Key Lab Basis & New Drug Dev Nat & Nucl Drug, Beijing 100193, Peoples R China

[2] Huanghe Sci & Technol Coll, Comprehens Utilizat Edible & Med Plant Resources E, Zhengzhou Key Lab Synthet Biol Nat Prod, Zhengzhou Key Lab Med Resources Res, Zhengzhou 450006, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2024年 / 72卷 / 09期

关键词：

asterric acid; structures; NMR analysis; bioactivities; biosynthesis; CHLORINATED DIPHENYL ETHERS; EMODIN-O-METHYLTRANSFERASE; ENDOPHYTIC FUNGUS; SECONDARY METABOLITES; ASPERGILLUS-TERREUS; PESTHEIC ACID; EMODINANTHRONE OXYGENASE; PENICILLIUM-FREQUENTANS; CORYNESPORA-CASSIICOLA; DIHYDROGEODIN OXIDASE;

D O I：

10.1021/acs.jafc.3c06690

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Asterric acid and its analogs belong to diphenyl ethers (DPEs) with multiple substitutions on A/B aromatic rings. This member of DPEs originates from the polyketide pathway and displays a wide range of biological effects. Though the structures of asterric acid analogs are not complex, there were only more than 50 asterric acid analogs found in nature from 1960 to 2023. In this review, the structures, bioactivities, and biosynthesis of asterric acid analogs are summarized. More importantly, the empirical rule about the shielding effect of B-ring on H-6 is suggested, and this provides a convenient and useful way to analyze the NMR spectral data of asterric acid analogs, based on which the chemical shift values of the A-ring in some asterric acid analogs are revised.

引用

页码：4518 / 4537

页数：20

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