Circadian biology to advance therapeutics for mood disorders

被引：7
|
作者：
Bhatnagar, Apoorva [1 ,2 ]
Murray, Greg [2 ]
Ray, Sandipan [1 ]
机构：
[1] Indian Inst Technol Hyderabad, Dept Biotechnol, Sangareddy 502284, Telangana, India
[2] Swinburne Univ Technol, Ctr Mental Hlth, Melbourne, Vic, Australia
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2023年 / 44卷 / 10期
基金：
英国惠康基金;
关键词：
GENE-EXPRESSION; CLOCK; RHYTHMS; TIME; DEPRESSION; MELATONIN; METABOLISM; ACTIVATION; REWARD; ATLAS;
D O I：
10.1016/j.tips.2023.07.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian and sleep dysfunction in the pathogenesis of mood disorders, and there is growing interest in these chronobiological pathways as a focus for treatment innovation. We review contemporary evidence in three promising areas in circadian-clock-based therapeutics in mood disorders: targeting the circadian system informed by mechanistic molecular advances; time-tailoring of medications; and personalizing treatment using circadian parameters. We also consider the limitations and challenges in accelerating the development of new circadian-informed pharmacotherapies for mood disorders.
引用
收藏
页码：689 / 704
页数：16
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