The sFlt-1/PlGF Ratio in Pregnant Patients Affected by COVID-19

被引：8

作者：

Kosinska-Kaczynska, Katarzyna ^{[1
]}

Malicka, Ewa ^{[1
]}

Szymusik, Iwona ^{[1
]}

Dera, Norbert ^{[1
]}

Pruc, Michal ^{[2
]}

Feduniw, Stepan ^{[3
]}

Rafique, Zubaid ^{[4
]}

Szarpak, Lukasz ^{[4
,5
]}

机构：

[1] Ctr Postgrad Med Educ, Dept Obstet Perinatol & Neonatol, PL-01813 Warsaw, Poland

[2] Polish Soc Disaster Med, Res Unit, PL-05816 Warsaw, Poland

[3] Univ Hosp Zurich, Dept Gynecol, CH-8005 Zurich, Switzerland

[4] Baylor Coll Med, Henry JN Taub Dept Emergency Med, Houston, TX 77030 USA

[5] Mar Sklodowska Curie Med Acad, Inst Outcomes Res, PL-00136 Warsaw, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 03期

关键词：

COVID-19; SARS-CoV-2; sFlt-1; PlGF ratio; RAS; placental dysfunction; pregnancy; SARS-COV-2; INFECTION; PREECLAMPSIA; IMPACT; WOMEN;

D O I：

10.3390/jcm12031059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

COVID-19 in pregnant women increases the risk of adverse pregnancy outcomes, including preeclampsia. This meta-analysis aimed to examine the effect of SARS-CoV-2 infection on sFlt-1/PIGF ratio during pregnancy. The study was designed as a systematic review and meta-analysis. PubMed, Web of Science, Embase and Cochrane Library were searched for relevant studies reporting the sFlt-1/PlGF ratio in pregnant women with COVID-19. Results were compared using meta-analysis by the Mantel-Haenszel method. A total of 7 studies were included in the analysis. sFlt-1/PlGF ratios between COVID-19 positive vs. negative women were 45.8 +/- 50.3 vs. 37.4 +/- 22.5, respectively (SMD = 1.76; 95% CI: 0.43 to 3.09; p = 0.01). sFlt-1/PlGF ratios between asymptomatic vs. symptomatic patients were 49.3 +/- 35.7 vs. 37.1 +/- 25.6 (SMD = 0.30; 95% CI: -0.35 to 0.95; p = 0.36). sFlt-1/PlGF ratio in non-severe group was 30.7 +/- 56.5, compared to 64.7 +/- 53.5 for severe patients (SMD = -1.88; 95% CI: -3.77 to 0.01; p = 0.05). sFlt-1/PlGF ratios in COVID-19 patients, with and without hypertensive disease of pregnancy, were 187.0 +/- 121.8 vs. 21.6 +/- 8.6, respectively (SMD = 2.46; 95% CI: 0.99 to 3.93; p = 0.001). Conclusions: Patients with COVID-19, as compared to patients without COVID-19, were characterized by higher sFlt-1/PlGF ratio. Moreover, severe COVID-19 and SARS-CoV-2 infection in hypertensive pregnant women was related to significantly higher sFlt-1/PlGF ratio.

引用

页数：9

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