Lessons learned from the application of the HEcoPerMed guidance to three modeling case studies

被引：1

作者：

Nagy, Balazs ^{[1
,5
]}

Zelei, Tamas ^{[1
]}

Vellekoop, Heleen ^{[2
]}

Huygens, Simone ^{[2
]}

Versteegh, Matthijs ^{[2
]}

Moelken, Maureen Rutten-van ^{[2
,3
]}

Koleva-Kolarova, Rositsa ^{[4
]}

Tsiachristas, Apostolos ^{[4
]}

Wordsworth, Sarah ^{[4
]}

Szilberhorn, Laszlo ^{[1
]}

机构：

[1] Syreon Res Inst, Budapest, Hungary

[2] Erasmus Univ, Inst Med Technol Assessment, NL-3000 DR Rotterdam, Netherlands

[3] Erasmus Univ, Erasmus Sch Hlth Policy & Management, Rotterdam, Netherlands

[4] Univ Oxford, Hlth Econ Res Ctr, Oxford, England

[5] Semmelweis Univ, Ctr Hlth Technol Assessment, Budapest, Hungary

来源：

PERSONALIZED MEDICINE | 2023年 / 20卷 / 04期

基金：

欧盟地平线“2020”;

关键词：

cost-effectiveness; economic evaluation; genetic testing; guidance; modeling; personalized medicine; recommendations;

D O I：

10.2217/pme-2023-0040

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: The HEcoPerMed consortium developed a methodological guidance for the harmonization and improvement of economic evaluations in personalized medicine. Materials & methods: In three therapeutic areas, health economic models were developed to scrutinize the recommendations of the guidance. Results: Altogether, 20 of the 23 recommendations of the guidance were addressed by the models. Seven recommendations were applied in all studies, six in two of the studies and seven in one of the studies. Recommendations with an essential role on the final conclusions of the analyses were identified in each study. Conclusion: The guidance was found to be best used as a tool to identify and prioritize issues, verify solutions and justify decisions during the economic analysis of personalized interventions.

引用

页码：401 / 411

页数：11

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