Synthesis and evaluation of antipyrine derivatives bearing a thiazole moiety as antibacterial and antifungal agents

One of the best ways to design new biocidal agents is synthesizing hybrid molecules. So, new series of antipyrine-bearing thiazole moiety were synthesized using 4-antipyrinecarboxaldehyde thiosemicarbazones 1a-e. Cyclization of thiosemicarbazone derivatives 1a-e with ethyl 2-chloroacetate, ethyl 2-chloropropanoate, 1-chloropropan-2-one (chloroacetone) and 2-bromo-1-phenylethanone (phenacyl bromide) afforded the corresponding thiazolidin-4-ones 2a-e, 5-methyl-thiazolidin-4-ones 3a-e, 4-methylthiazoles 4a-e and 4-phenylthiazoles 5a-e, respectively. The antibacterial and antifungal activates for the synthesized compounds were investigated. [GRAPHICS] .