N-Desmethylmajusculamide B, a lipopeptide isolated from the Okinawan cyanobacterium Okeania hirsuta

被引：0

作者：

Zhang, Bo-Tao ^{[1
]}

Nishino, Haruka ^{[1
]}

Kawabe, Ryoya ^{[1
]}

Kamio, Michiya ^{[1
]}

Watanabe, Ryuichi ^{[2
]}

Uchida, Hajime ^{[2
]}

Satake, Masayuki

Nagai, Hiroshi ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Dept Ocean Sci, Tokyo, Japan

[2] Japan Fisheries Res & Educ Agcy, Fisheries Technol Inst, Yokohama, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2024年 / 88卷 / 05期

关键词：

lipopeptide; cyanobacteria; Okeania hirsuta; Marfey's method; semisynthesis; DERIVATIVES;

D O I：

10.1093/bbb/zbae015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new lipopeptide, N-desmethylmajusculamide B (1), was isolated from the Okinawan cyanobacterium Okeania hirsuta along with 2 known compounds majusculamide A (2) and majusculamide B (3). The planar structure of (1) was elucidated by a detailed analysis of mass spectrometry and nuclear magnetic resonance spectra. The absolute configurations of the amino acid residues were determined using Marfey's analysis. The configuration of C-16 in the alpha-methyl-beta-keto-decanoyl moiety was determined unambiguously to be S by conducting a semisynthesis of N-desmethylmajusculamide B from 3. The cytotoxicity against mouse L1210 leukemia cells was evaluated for majusculamides (1-3). Graphical Abstract N-Desmethylmajusculamide B, a novel lipopeptide was isolated from the marine cyanobacterium Okeania hirsuta.

引用

页码：517 / 521

页数：5

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