Synthesis and biological activities of substituted 1,3,4-oxadiazolines

被引：0
|
作者：
Dalloul, Hany M. [1 ]
Yunis, Kholoud R. Abu [1 ]
机构：
[1] Aqsa Univ Gaza, Fac Appl Sci, Dept Chem, POB 4051, Gaza 76888, Gaza Strip, Palestine
来源：
ORGANIC COMMUNICATIONS | 2023年 / 16卷 / 01期
关键词：
1; 3; 4-Oxadiazolines; N-acylhydrazones; spiro-oxadiazole; oxidative cyclization; MECHANISM;
D O I：
10.25135/acg.oc.146.2302.2717
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new series of N-butyryl-1,3,4-oxadiazolines were synthesized via oxidative cyclization reaction of different benzoyl hydrazones with butyric anhydride. The structures of obtained compounds were confirmed by IR, MS, 1H NMR, 13C NMR and Elemental analysis methods and are in full agreement with their molecular structure. The synthesized 1,3,4-oxadiazolines were screened for in vitro for their biological activity against a variety of bacterial strains (Euterococci, Escherichia coli, Staphylococcus aureus, Klebsiella spp, Proteus spp, and fungi (Aspergillus niger, Candida albicans), employing the nutrient agar disc diffusion method. The obtained results showed that these compounds have good inhibition against the tested pathogens.
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页码：35 / 45
页数：11
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