Zuczkowski et al.'s KUB model clarified three epistemic stances: Knowing/Certain, Not Knowing Whether and Believing/Uncertain, and Unknowing/Neither Certain nor Uncertain, according to the speakers' communicated information, and delineated three types of markers: macro-markers, micro-markers, and morphosyntactic markers. The model has seldom been applied to L2 instruction. To address this gap, the study examines the effect of grade and genre-specific questions on Chinese L2 speakers' choice of epistemic markers with reference to the model by analyzing the self-built corpus consisting of the oral data collected from two groups: Group One consisting of 20 sophomores and Group Two comprising 20 first-year graduate students. The participants were required to answer four genre-specific questions covering argumentation, description, narration, and exposition. The results show that the two group members use similar epistemic markers (EMs) for the Knowing/Certain and Not Knowing Whether and Believing /Uncertain positions but present a slight discrepancy in Unknowing/Neither Certain nor Uncertain stance-taking. The genre-based questions demonstrate a significant effect on the graduate speakers' use of the micro-markers and morphosyntactic markers for the Not Knowing Whether and Believing/Uncertain and the macro-markers and morphosyntactic markers for the Unknowing/Neither Certain nor Uncertain. It indicates that high-grade speakers are more sensitive to genre-based messages, though they use rather limited epistemic forms as low-grade speakers do. The findings suggest that English as a Second Language (ESL) oral instruction in China should be reformed and supplemented with diverse EMs to allow the speakers to take the epistemic stance they are comfortable with.