A disease-modifying approach to the treatment of IgA nephropathy targeting mucosal IgA synthesis and beyond

被引：5
|
作者：
Coppo, Rosanna [1 ,2 ]
机构：
[1] Regina Margher Hosp, Fdn Riverca Molinette, Turin, Italy
[2] Fdn Ric Molinette, Via Valeggio 41, I-10129 Turin, Italy
来源：
KIDNEY INTERNATIONAL | 2023年 / 103卷 / 02期
关键词：
D O I：
10.1016/j.kint.2022.10.019
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The benefits and risks of systemic corticosteroids in the treatment of IgA nephropathy are still controversial. Part A results of the Efficacy and Safety of Nefecon in Patients With Primary IgA Nephropathy (NefIgArd) trial provide significant effects on decrease in proteinuria and protection from estimated glomerular filtration rate decline after 9 months of treatment with budesonide (Nefecon). Targeting the initiating pathogenetic event in the gut-associated lymphoid tissue would offer a and possible multiple effects of this treatment are critically discussed.
引用
收藏
页码：258 / 261
页数：4
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